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畜牧与生物技术杂志(英文版)
中国科学技术协会
畜牧与生物技术杂志(英文版)

中国科学技术协会

李德发

季刊

1674-9782

zgxm@cau.edu.cn;xmzz@cau.edu.cn

010-62734403/2723

100193

中国农业大学西校区动物科技学院Journal of Animal Science and Biotechnology编辑部

畜牧与生物技术杂志(英文版)/Journal Journal of Animal Science and BiotechnologyCSCDCSTPCD北大核心SCI
查看更多>>定位为国内外公开发行的专业学术期刊，宗旨是立足国内，面向国际，为国内外畜牧科技工作者提供国际化学术共享的园地，促进我国与国际上其他国家在畜牧科学领域的交流；让中国畜牧科技走向世界，让世界了解中国畜牧科技。
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    Embryonic thermal manipulation:a potential strategy to mitigate heat stress in broiler chickens for sustainable poultry production

    Sadid Al AmazBirendra Mishra
    1347-1375页
    查看更多>>摘要：Due to high environmental temperatures and climate change,heat stress is a severe concern for poultry health and production,increasing the propensity for food insecurity.With climate change causing higher temperatures and erratic weather patterns in recent years,poultry are increasingly vulnerable to this environmental stressor.To mitigate heat stress,nutritional,genetic,and managerial strategies have been implemented with some success.How-ever,these strategies did not adequately and sustainably reduce the heat stress.Therefore,it is crucial to take proac-tive measures to mitigate the effects of heat stress on poultry,ensuring optimal production and promoting poultry well-being.Embryonic thermal manipulation(TM)involves manipulating the embryonic environment's temperature to enhance broilers'thermotolerance and growth performance.One of the most significant benefits of this approach is its cost-effectiveness and saving time associated with traditional management practices.Given its numerous advan-tages,embryonicTM is a promising strategy for enhancing broiler production and profitability in the poultry industry.TM increases the standard incubation temperature in the mid or late embryonic stage to induce epigenetic thermal adaption and embryonic metabolism.Therefore,this review aims to summarize the available literature and scientific evidence of the beneficial effect of pre-hatch thermal manipulation on broiler health and performance.
      原文链接:
    • 万方数据
    • 维普

    The application of omics technologies for understanding tropical plants-based bioactive compounds in ruminants:a review

    Metha WanapatGamonmas DagaewSukruthai SommaiMaharach Matra...
    1376-1390页
    查看更多>>摘要：Finding out how diet impacts health and metabolism while concentrating on the functional qualities and bio-active components of food is the crucial scientific objective of nutritional research.The complex relationship between metabolism and nutrition could be investigated with cutting-edge"omics"and bioinformatics techniques.This review paper provides an overview of the use of omics technologies in nutritional research,with a particular emphasis on the new applications of transcriptomics,proteomics,metabolomics,and genomes in functional and bio-logical activity research on ruminant livestock and products in the tropical regions.A wealth of knowledge has been uncovered regarding the regulation and use of numerous physiological and pathological processes by gene,mRNA,protein,and metabolite expressions under various physiological situations and guidelines.In particular,the compo-nents of meat and milk were assessed using omics research utilizing the various methods of transcriptomics,prot-eomics,metabolomics,and genomes.The goal of this review is to use omics technologies-which have been steadily gaining popularity as technological tools-to develop new nutritional,genetic,and leadership strategies to improve animal products and their quality control.We also present an overview of the new applications of omics technologies in cattle production and employ nutriomics and foodomics technologies to investigate the microbes in the rumen ecology.Thus,the application of state-of-the-art omics technology may aid in our understanding of how species and/or breeds adapt,and the sustainability of tropical animal production,in the long run,is becoming increasingly impor-tant as a means of mitigating the consequences of climate change.
      原文链接:
    • 万方数据
    • 维普

    Endotoxin-induced alterations of adipose tissue function:a pathway to bovine metabolic stress

    Miguel ChiriviG.Andres Contreras
    1391-1407页
    查看更多>>摘要：During the periparturient period,dairy cows exhibit negative energy balance due to limited appetite and increased energy requirements for lactogenesis.The delicate equilibrium between energy availability and expenditure puts cows in a state of metabolic stress characterized by excessive lipolysis in white adipose tissues(AT),increased pro-duction of reactive oxygen species,and immune cell dysfunction.Metabolic stress,especially in AT,increases the risk for metabolic and inflammatory diseases.Around parturition,cows are also susceptible to endotoxemia.Bacterial-derived toxins cause endotoxemia by promoting inflammatory processes and immune cell infiltration in different organs and systems while impacting metabolic function by altering lipolysis,mitochondrial activity,and insulin sensitivity.In dairy cows,endotoxins enter the bloodstream after overcoming the defense mechanisms of the epi-thelial barriers,particularly during common periparturient conditions such as mastitis,metritis,and pneumonia,or after abrupt changes in the gut microbiome.In the bovine AT,endotoxins induce a pro-inflammatory response and stimulate lipolysis in AT,leading to the release of free fatty acids into the bloodstream.When excessive and pro-tracted,endotoxin-induced lipolysis can impair adipocyte's insulin signaling pathways and lipid synthesis.Endotoxin exposure can also induce oxidative stress in AT through the production of reactive oxygen species by inflammatory cells and other cellular components.This review provides insights into endotoxins'impact on AT function,highlight-ing the gaps in our knowledge of the mechanisms underlying AT dysfunction,its connection with periparturient cows'disease risk,and the need to develop effective interventions to prevent and treat endotoxemia-related inflam-matory conditions in dairy cattle.
      原文链接:
    • 万方数据
    • 维普

    Staphylococcus aureus and biofilms:transmission,threats,and promising strategies in animal husbandry

    Mengda SongQi TangYakun DingPeng Tan...
    1408-1423页
    查看更多>>摘要：Staphylococcus aureus(S.aureus)is a common pathogenic bacterium in animal husbandry that can cause diseases such as mastitis,skin infections,arthritis,and other ailments.The formation of biofilms threatens and exacerbates S.aureus infection by allowing the bacteria to adhere to pathological areas and livestock product surfaces,thus trig-gering animal health crises and safety issues with livestock products.To solve this problem,in this review,we provide a brief overview of the harm caused by S.aureus and its biofilms on livestock and animal byproducts(meat and dairy products).We also describe the ways in which S.aureus spreads in animals and the threats it poses to the livestock industry.The processes and molecular mechanisms involved in biofilm formation are then explained.Finally,we discuss strategies for the removal and eradication of S.aureus and biofilms in animal husbandry,including the use of antimicrobial peptides,plant extracts,nanoparticles,phages,and antibodies.These strategies to reduce the spread of S.aureus in animal husbandry help maintain livestock health and improve productivity to ensure the ecologically sustainable development of animal husbandry and the safety of livestock products.
      原文链接:
    • 万方数据

    The protective role of prebiotics and probiotics on diarrhea and gut damage in the rotavirus-infected piglets

    Heng YangXiangqi FanXiangbing MaoBing Yu...
    1424-1448页
    查看更多>>摘要：Rotavirus is one of the pathogenic causes that induce diarrhea in young animals,especially piglets,worldwide.However,nowadays,there is no specific drug available to treat the disease,and the related vaccines have no obvious efficiency in some countries.Via analyzing the pathogenesis of rotavirus,it inducing diarrhea is mainly due to disturb enteric nervous system,destroy gut mucosal integrity,induce intracellular electrolyte imbalance,and impair gut microbiota and immunity.Many studies have already proved that prebiotics and probiotics can mitigate the damage and diarrhea induced by rotavirus infection in hosts.Based on these,the current review summarizes and discusses the effects and mechanisms of prebiotics and probiotics on rotavirus-induced diarrhea in piglets.This information will highlight the basis for the swine production utilization of prebiotics and probiotics in the prevention or treatment of rotavirus infection in the future.
      原文链接:
    • 万方数据
    • 维普

    Proteo-transcriptomic profiles reveal key regulatory pathways and functions of LDHA in the ovulation of domestic chickens(Gallus gallus)

    Ruixue NieWenhui ZhangHaoyu TianJunying Li...
    1449-1465页
    查看更多>>摘要：Background In poultry,the smooth transition of follicles from the preovulatory-to-postovulatory phase impacts egg production in hens and can benefit the poultry industry.However,the regulatory mechanism underlying follicular ovulation in avians is a complex biological process that remains unclear.Results Critical biochemical events involved in ovulation in domestic chickens(Gallus gallus)were evaluated by transcriptomics,proteomics,and in vitro assays.Comparative transcriptome analyses of the largest preovulatory follicle(F1)and postovulatory follicle(POF1)in continuous laying(CL)and intermittent laying(IL)chickens indicated the greatest difference between CL_F1 and IL_F1,with 950 differentially expressed genes(DEGs),and the smallest difference between CL_POF1 and IL_POF1,with 14 DEGs.Additionally,data-independent acquisition proteomics revealed 252 differentially abundant proteins between CL_F1 and IL_F1.Perivitelline membrane synthesis,steroid biosynthesis,lysosomes,and oxidative phosphorylation were identifiied as pivotal pathways contributing to ovulation regulation.In particular,the regulation of zona pellucida sperm-binding protein 3,plasminogen activator,cathepsin A,and lactate dehydrogenase A(LDHA)was shown to be essential for ovulation.Furthermore,the inhibition of LDHA decreased cell viability and promoted apoptosis of ovarian follicles in vitro.Conclusions This study reveals several important biochemical events involved in the process of ovulation,as well as crucial role of LDHA.These findings improve our understanding of ovulation and its regulatory mechanisms in avian species.
      原文链接:
    • 万方数据
    • 维普

    Large-scale transcriptomic and genomic analyses reveal a novel functional gene SERPINB6 for chicken carcass traits

    Di ZhaoRanran LiuXiaodong TanHuimin Kang...
    1466-1481页
    查看更多>>摘要：Background Carcass traits are crucial indicators of meat production efficiency.However,the molecular regulatory mechanisms associated with these traits remain unclear.Results In this study,we conducted comprehensive transcriptomic and genomic analyses on 399Tiannong par-tridge chickens to identify key genes and variants associated with carcass traits and to elucidate the underlying regu-latory mechanisms.Based on association analyses with the elastic net(EN)model,we identified 12 candidate genes(AMY1A,AP3B2,CEBPG,EEF2,EIF4EBP1,FGFR1,FOXD3,GOLM1,LOC107052698,PABPC1,SERPINB6 and TBC1D16)for 4 carcass-related traits,namely live weight,dressed weight,eviscerated weight,and breast muscle weight.SERPINB6 was identified as the only overlapping gene by 3 analyses,EN model analysis,weighted gene co-expression network analysis and differential expression analysis.Cell-level experiments confirmed that SERPINB6 promotes the prolifera-tion of chicken DF1 cellsand primary myoblasts.Further expression genome-wide association study and association analysis indicated that rs317934171 is the critical site that enhances SERPINB6 expression.Furthermore,a dual-lucif-erase reporter assay proved that gga-miR-1615 targets the 3'UTR ofSERPINB6.Conclusions Collectively,our findings reveal that SERPINB6 serves as a novel gene for chicken carcass traits by pro-moting fibroblast and myoblast proliferation.Additionally,the downstream variant rs317934171 regulates SERPINB6 expression.These results identify a new target gene and molecular marker for the molecular mechanisms of chicken carcass traits.
      原文链接:
    • 万方数据

    Significant genomic introgression from grey junglefowl(Gallus sonneratii)to domestic chickens(Gallus gallus domesticus)

    Xiurong ZhaoJunhui WenXinye ZhangJinxin Zhang...
    1482-1493页
    查看更多>>摘要：Background Chicken is one of the most numerous and widely distributed species around the world,and many studies support the multiple ancestral origins of domestic chickens.The research regarding the yellow skin pheno-type in domestic chickens(regulated by BCO2)likely originating from the grey junglefowl serves as crucial evidence for demonstrating the multiple origins of chickens.However,beyond the BCO2 gene region,much remains unknown about the introgression from the grey junglefowl into domestic chickens.Therefore,in this study,based on whole-genome data of 149 samples including 4 species of wild junglefowls and 13 local domestic chicken breeds,we explored the introgression events from the grey junglefowl to domestic chickens.Results We successfully detected introgression regions besides BCO2,including two associated with growth trait(IGFBP2 and TKT),one associated with angiogenesis(TIMP3)and two members of the heat shock protein family(HSPB2 and CRYAB).Our findings suggest that the introgression from the grey junglefowl may impact the growth perfor-mance of chickens.Furthermore,we revealed introgression events from grey junglefowl at the BCO2 region in mul-tiple domestic chicken breeds,indicating a phenomenon where the yellow skin phenotype likely underwent strong selection and was retained.Additionally,our haplotype analysis shed light on BCO2 introgression event from different sources of grey junglefowl into domestic chickens,possibly suggesting multiple genetic flows between the grey junglefowl and domestic chickens.Conclusions In summary,our findings provide evidences of the grey junglefowl contributing to the genetic diversity of domestic chickens,laying the foundation for a deeper understanding of the genetic composition within domestic chickens,and offering new perspectives on the impact of introgression on domestic chickens.
      原文链接:
    • 万方数据
    • 维普

    Exploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet

    Guangliang GaoRui LiuSilu HuMengnan He...
    1494-1511页
    查看更多>>摘要：Background Goose,descendants of migratory ancestors,have undergone extensive selective breeding,resulting in their remarkable ability to accumulate fat in the liver and exhibit a high tolerance for significant energy intake.As a result,goose offers an excellent model for studying obesity,metabolic disorders,and liver diseases in mammals.Although the impact of the three-dimensional arrangement of chromatin within the cell nucleus on gene expression and transcriptional regulation is widely acknowledged,the precise functions of chromatin architecture reorganization during fat deposition in goose liver tissues still need to be fully comprehended.Results In this study,geese exhibited more pronounced changes in the liver index and triglyceride(TG)content following the consumption of the high-fat diet(HFD)than mice without significant signs of inflammation.Addition-ally,we performed comprehensive analyses on 10 goose liver tissues(5 HFD,5 normal),including generating high-resolution maps of chromatin architecture,conducting whole-genome gene expression profiling,and identifying H3K27ac peaks in the livers of geese and mice subjected to the HFD.Our results unveiled a multiscale restructuring of chromatin architecture,encompassing Compartment A/B,topologically associated domains,and interactions between promoters and enhancers.The dynamism of the three-dimensional genome architecture,prompted by the HFD,assumed a pivotal role in the transcriptional regulation of crucial genes.Furthermore,we identified genes that regulate chromatin conformation changes,contributing to the metabolic adaptation process of lipid deposition and hepatic fat changes in geese in response to excessive energy intake.Moreover,we conducted a cross-species analysis comparing geese and mice exposed to the HFD,revealing unique characteristics specific to the goose liver compared to a mouse.These chromatin conformation changes help elucidate the observed characteristics of fat deposition and hepatic fat regulation in geese under conditions of excessive energy intake.Conclusions We examined the dynamic modifications in three-dimensional chromatin architecture and gene expression induced by an HFD in goose liver tissues.We conducted a cross-species analysis comparing that of mice.Our results contribute significant insights into the chromatin architecture of goose liver tissues,offering a novel per-spective for investigating mammal liver diseases.
      原文链接:
    • 万方数据
    • 维普

    Identification of porcine fast/slow myogenic exosomes and their regulatory effects on lipid accumulation in intramuscular adipocytes

    Tiantian ZhaoTingting TianHe YuChaoyue Cao...
    1512-1527页
    查看更多>>摘要：Background Pork quality is affected by the type of muscle fibers,which is closely related to meat color,tender-ness and juiciness.Exosomes are tiny vesicles with a diameter of approximately 30-150 nm that are secreted by cells and taken up by recipient cells to mediate communication.Exosome-mediated muscle-fat tissue crosstalk is a newly discovered mechanism that may have an important effect on intramuscular fat deposition and with that on meat quality.Various of adipose tissue-derived exosomes have been discovered and identified,but the identification and function of muscle exosomes,especially porcine fast/slow myotube exosomes,remain unclear.Here,we first isolated and identified exosomes secreted from porcine extensor digitorum longus(EDL)and soleus(SOL),which represent fast and slow muscle,respectively,and further explored their effects on lipid accumulation in longissimus dorsi adipocytes.Results Porcine SOL-derived exosomes(SOL-EXO)and EDL-derived exosomes(EDL-EXO)were first identified and their average particle sizes were approximately 84 nm with double-membrane disc-shapes as observed via transmission electron microscopy and scanning electron microscopy.Moreover,the intramuscular fat content of the SOL was greaterthan that of the EDL at 180 days of age,because SOL intramuscular adipocytes had a stronger lipid-accumulating capacity than those of the EDL.Raman spectral analysis revealed that SOL-EXO protein content was much greater than that of EDL-EXO.Proteomic sequencing identified 72 proteins that were significantly differen-tially expressed between SOL-EXO and EDL-EXO,31 of which were downregulated and 41 of which were upregulated in SOL-EXO.Conclusions Our findings suggest that muscle-fat tissue interactions occur partly via SOL-EXO promoting adipo-genic activity of intramuscular adipocytes.
      原文链接:
    • 万方数据
    • 维普