首页期刊导航|中国化学快报（英文版）
期刊信息/Journal information
中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
正式出版
收录年代

    The remarkable effect of amino hydrogen on membrane permeability and organelle staining of 1,8-naphthalimide dyes

    Zhifeng LiQinglong QiaoNing XuKai An...
    347-351页
    查看更多>>摘要：Membrane permeability and intracellular diffusion of fluorescent probes determine staining selectivity of intracellular substructures.However,the relationship between the molecular structure of fluorescent probes and their membrane permeability and intracellular distribution is poorly understood.In this paper,we reported a series of 1,8-naphthalimide dyes and carried out cell imaging experiments,and found that the presence of amino hydrogen in these dyes played a crucial role in their cell membrane permeabil-ity and intracellular distribution.The secondary amino group containing compounds 1-4 show excellent membrane permeability and strong fluorescence in living cells.While the tertiary amine containing dyes 5 and 6 can hardly permeate the cell membrane though they show extremely similar structure with com-pounds 2-4.Compound 1 can selectively image lipid droplets by selecting the wavelength of excitation light.With the specificity for lysosomes,2 and 4 have been used in long-term time-lapses imaging of lysosomal dynamics and tracking the process of lysosome-lysosome interaction,fusion and movement.The effect of hydrogen-containing amino substituent on the cell membrane permeability of fluorescent molecules is promising for the development of better biocompatible probes.
      原文链接:
    • 万方数据
    • 维普

    Intelligent design and construction of novel APN-based theranostic probe driven by advanced computational methods

    Yingli ZhuJie QianKunqian YuJing Hou...
    352-357页
    查看更多>>摘要：Multifunctional molecules with both optical signal and pharmacological activity play an important role in drug development,disease diagnosis,and basic theoretical research.Aminopeptidase N(APN),as a representative tumor biomarker with anti-tumor potential,still lacks a high-precision theranostic probe specifically targeting it.In this study,a novel quaternity design strategy for APN theranostic probe was developed.This proposed strategy utilizes advanced machine learning and molecular dynamics simula-tions,and cleverly employs the strategy of conformation-induced fluorescence recovery to achieve multi-objective optimization and integration of functional fragments.Through this strategy,a unique"Off-On"theranostic probe,ABTP-DPTB,was ingeniously constructed to light up APN through fluorescence restora-tion,relying on conformation-induced effects and solvent restriction.Differ from the common diagnostic probes,the intelligent design with non-substrated linkage makes ABTP-DPTB for long-term in-situ imag-ing.The fabricated probe was used for detecting and inhibiting APN in various environments,with a better in vitro inhibitory than golden-standard drug bestatin.
      原文链接:
    • 万方数据
    • 维普

    Free amino group-directed C(sp2)-H arylation of α-amino-β-aryl esters by palladium catalysis

    Yue GaoYu DuWeiping Su
    358-360页
    查看更多>>摘要：Native amino-directed palladium-catalyzed C(sp3)-H activation/functionalization has been developed for modification of α-amino acids and peptides.Herein a palladium(Ⅱ)-catalyzed C(sp2)-H arylation of α-amino-β-aryl esters has been disclosed,using the native amino as the directing group.A variety of chiralα-amino-β-aryl esters can be functionalized to give the corresponding ortho-substituted mono-and di-arylated products.
      原文链接:
    • 万方数据

    β-C(sp3)-H chlorination of amide derivatives via photoinduced copper charge transfer catalysis

    Yuhang HeChao TianGuanghui AnGuangming Li...
    361-365页
    查看更多>>摘要：An atom economic β-C(sp3)-H chlorination of amide derivatives has been developed.This mild protocol employs CuCl2 instead of palladium catalysts with atom-economic HCl as chlorine sources and enables the late-stage functionalization of medicine derivatives.Mechanism studies suggest a plausible visible light triggered ligand-to-metal charge transfer(LMCT)/1,4-hydrogen atom transfer(HAT)cascade.
      原文链接:
    • 万方数据

    Photo-induced 1,2-aryl migration of 2-chloro-1-arylpropanone under batch and flow conditions:Rapid,scalable and sustainable approach to 2-arylpropionic acids

    Qiao LiMinjie LiuMeifen JiangLi Wan...
    366-369页
    查看更多>>摘要：We report the photo-mediated 1,2-aryl migration of 2-chloro-1-arylpropanones to 2-arylpropionic acids using HCOONa as an acid scavenger.This pragmatically focused study obviates the multiple-step sequence in the industrially employed,ZnO-promoted rearrangement strategy,and offers rapid access to various 2-arylpropionic acids under environmentally friendly conditions.Furthermore,the successful transfer of this batch photochemistry to a continuous flow platform led to improved scalability and enabled the gram-scale synthesis of loxoprofen.
      原文链接:
    • 万方数据
    • 维普

    Artificial stepwise light harvesting system in water constructed by quadruple hydrogen bonding supramolecular polymeric nanoparticles

    Tangxin XiaoXiuxiu LiLiangliang ZhangKai Diao...
    370-373页
    查看更多>>摘要：Stepwise energy transfer is ubiquitous in natural photosynthesis,which greatly promotes the widespread use of solar energy.Herein,we constructed a supramolecular light harvesting system based on sequential energy transfer through the hierarchical self-assembly of M,which contains a cyanostilbene core flanked by two ureidopyrimidinone motifs,endowing itself with both aggregation-induced emission behavior and quadruple hydrogen bonding ability.The monomer M can self-assemble into hydrogen bonded polymers and then form supramolecular polymeric nanoparticles in water through a mini-emulsion process.The nanoparticles were further utilized to encapsulate the relay acceptor ESY and the final acceptor NDI to form a two-step FRET system.Tunable fluorescence including a white-light emission was successfully achieved.Our work not only shows a desirable way for the fabrication of efficient two-step light harvest-ing systems,but also shows great potential in tunable photoluminescent nanomaterials.
      原文链接:
    • 万方数据
    • 维普

    In situ crosslink polymerization induced long-lived multicolor supramolecular hydrogel based on modified β-cyclodextrin

    Yonghui SunLinnan JiangYong ChenYu Liu...
    374-379页
    查看更多>>摘要：The construction of hydrogels with good mechanical properties and phosphorescent properties is full of challenges.Herein,we report a supramolecular phosphorescent hydrogel with long lifetime,high tensile strength and self-healing property,which can be easily constructed through in-situ thermal-initiated polymerization of isocyanatoethyl acrylate-modified β-cyclodextrin(β-CD-DA)and acrylate-modified adamantane(Ad-DA),acrylic acid(AA),followed by the non-covalent association with carbon dots(CNDs).The lifetime of phosphorescent hydrogel can reach 1261 ms at room temperature,and the quantum yield is 11％.Importantly,through the efficient triplet to singlet Förster resonance energy trans-fer(TS-FRET),the phosphorescent hydrogel shows the good phosphorescence energy transfer property for organic dyes Rhodamine B and Eosin Y with the delayed fluorescence lifetime up to 730 ms and 585 ms as well as the energy transfer efficiency(ΦET)up to 99.9％and 99.3％,respectively.Moreover,owing to the host-guest interactions between β-CD-DA and Ad-DA,the three-dimensional cross-linked network phos-phorescent hydrogel can be easily stretched to 18 times of its original length,and can achieve self-healing of the cut surfaces within 30 min.These results will expand the scope of phosphorescent materials and provide new ideas and opportunities for materials science.
      原文链接:
    • 万方数据

    Microfluidic separation of particles by synergistic effect of geometry-induced hydrodynamics and magnetic field

    Du QiaoHongxia LiWeiping ZhuLili Zhu...
    380-385页
    查看更多>>摘要：Microfluidic combined with magnetic field have been demonstrated to be the promising solutions for fast and low-damage particles separation.However,the difficulties in the precise layout of magnets and accurate prediction of particle trajectories lead to under and over separation of target particles.A novel particle separation lab-on-chip(LOC)prototype integrated with microstructures and micropolar arrays is designed and characterized.Meanwhile,a numerical model for the separation of magnetic particles by the synergistic effect of geometry-induced hydrodynamics and magnetic field is constructed.The effect of geometry and magnetic field layout on particle deflection is systematically analyzed to implement ac-curate prediction of particle trajectories.It is found that the separation efficiency of magnetic particles increased from 50.2％to 91.7％and decreased from 88.6％to 85.7％in the range of depth factors from 15 μm to 27 μm and width factors from 30 μm to 60 μm,respectively.In particular,the combined effect of the offset distance of permanent magnets and the distance from the main flow channel exhibits a significant difference from the conventional perception.Finally,the developed LOC prototype was gener-alized for extension to arbitrary systems.This work provides a new insight and robust method for the microfluidic separation of magnetic particles.
      原文链接:
    • 万方数据
    • 维普

    A coating strategy on titanium implants with enhanced photodynamic therapy and CO-based gas therapy for bacterial killing and inflammation regulation

    Liang ChengBingshuai ZhouManlin QiXiaolin Sun...
    386-395页
    查看更多>>摘要：Antimicrobial photodynamic therapy(aPDT)has been considered a noninvasive and effective modality against the bacterial infection of peri-implantitis,especially the aPDT triggered by near-infrared(NIR)light due to the large penetration depth in tissue.However,the complexity of hypoxia microenviron-ments and the distance of aPDT sterilization still pose challenges before realizing the aPDT clinical ap-plication.Due to the long lifespan and transmission distance of therapeutic gas molecules,we design a multi-functional gas generator that combines aPDT as well as O2 and CO gas release function,which can solve the problem of hypoxia(O2)in PDT and the problem of inflammation regulation(CO)in the distal part of peri-implant inflammation under near-infrared(NIR)irradiation.In the composite nanoplatform that spin-coated on the surface of titanium implants,up-conversion nanoparticles(UCNPs)were involved in converting the NIR to visible,which further excites the partially oxidized stannic sulfide(SnS2),real-izing the therapeutic gas release.Indocyanine green(ICG)was further integrated to enhance the aPDT performance(Ti-U@SnS2/I).Therefore,reactive oxygen species(ROS),CO,and O2 can be controllably ad-ministered via a composite nano-platform mediated by a single NIR light(808 nm).This implant surface modification strategy could achieve great self-enhancement antibacterial effectiveness and regulate the lingering questions,such as relieving the anoxic microenvironment and reaching deep infection sites,providing a viable antibiotic-free technique to combat peri-implantitis.
      原文链接:
    • 万方数据
    • 维普

    Selective nickel-electrocatalyzed benzylic C-H oxygenation of functionalized alkyl arenes

    Shunyao TangSiyi WangDongmei ZhangXinxing Zhang...
    396-401页
    查看更多>>摘要：Herein,a site-selective paired electrochemical C-H oxidation of functionalized alkyl arenes promoted by nickel catalyst is disclosed.A Ni(ll)-dioxygen species formed in situ efficiently enable the oxidation pro-cess under mild conditions with a broad substrate scope with excellent functional group compatibilities,such as free carboxylic acid,aldehyde,halogen(including aryl iodide),amide and amino acid.The use of the nickel catalyst in combination with water provides a safe,green and economical method for oxidation of a range of molecules varying in complexity and drug derivatives,demonstrating its potential applica-tion in organic synthesis and the pharmaceutical industry.Reaction outcomes and mechanistic studies re-vealed the key role of the in situ Ni(Ⅱ)-dioxygen species for the subsequent oxidation of C(sp3)-H bonds,and short-lived reactive intermediates(aryl radical cation)was rapidly captured by the combination of a bipolar ultramicroelectrode(BUME)with nano-electrospray ionization mass spectrometry.
      原文链接:
    • 万方数据
    • 维普