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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    Engineering particles towards 3D supraballs-based passive cooling via grafting CDs onto colloidal photonic crystals

    Jie WuXiaoqing YuGuoxing LiSu Chen...
    457-463页
    查看更多>>摘要：Particle engineering has opened the floodgates to material science in both fundamental and application field.However,covalent interactions have not yet been adequately designed in the particle engineering for functional colloidal photonic crystals(CPCs).Herein,we achieved covalent coupling between carboxyl-rich poly(styrene-acrylic acid)(P(St-AA))monodispersed colloidal particles and amine-rich carbon dots(CDs)based on an feasible and universal particle engineering strategy.The designed CDs-grafted P(St-AA)monodispersed colloidal particles initiate a hydrogen bond-driven assembly mode and ensure the con-struction of large-scale crack-free CPCs.Moreover,the CDs equipped with selective broad-band absorp-tion capacity could improve the saturation of structural colors for high-visibility CPCs.Furthermore,an injectable photonic hydrogel(IPH)is developed to design CPC supraball hydrogel via integrating the CDs-grafted P(St-AA)CPC supraballs with supramolecular hydrogel.Combining superior flexibility,sufficient self-healing capacity of supramolecular hydrogel with visual optical information of our CPC supraballs,a cyclically reversible coding and decoding system was developed.Meanwhile,we firstly demonstrated the novel strategy of 3D supraballs-based passive cooling.The designed 3D CPC supraball hydrogel presents nearly full observation angle reflections behavior and excellent water evaporation capacity and achieves 3.6 ℃ temperature drops,showing the application advantages in 3D thermal management.This work not only provides a new insight for manipulating optical properties of CPCs,but also demonstrates an easy-to-perform platform,as well as indicates the direction for the promising application of CPCs.
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    MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids

    Jing ChenPeisi XiePengfei WuYu He...
    464-468页
    查看更多>>摘要：Cancer cell spheroids(CCS)are a valuable three-dimensional cell model in cancer studies because they could replicate numerous characteristics of solid tumors.Increasing researches have used matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI)to investigate the spatial distribu-tion of endogenous compounds(e.g.,lipids)in CCS.However,only limited lipid species can be detected owing to a low ion yield by using MALDI.Besides,it is still challenging to fully characterize the structural diversity of lipids due to the existence of isomeric/isobaric species.Here,we carried out the initial ap-plication of MALDI coupled with laser-postionization(MALDI-2)and trapped ion mobility spectrometry(TIMS)imaging in HCT116 colon CCS to address these challenges.We demonstrated that MALDI-2 is ca-pable of detecting more number and classes of lipids in HCT116 colon CCS with higher signal intensities than MALDI.TIMS could successfully separate numerous isobaric/isomeric species of lipids in CCS.Inter-estingly,we found that some isomeric/isobaric species have totally different spatial distributions in colon CCS.Further MS/MS imaging analysis was employed to determine the compositions of fatty acid chains for isomeric species by examining disparities in signal intensities and spatial distributions of product ions.This work stresses the robust ability of TIMS and MALDI-2 imaging in analyzing endogenous lipids in CCS,which could potentially become powerful tools for future cancer studies.
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    Coupling WO3-x dots-encapsulated metal-organic frameworks and template-free branched polymerization for dual signal-amplified electrochemiluminescence biosensing

    Fei YinErli YangXue GeQian Sun...
    469-474页
    查看更多>>摘要：Developing accurate and sensitive DNA methyltransferase(MTase)analysis methods is essential for early clinical diagnosis and development of antimicrobial drug targets.In this work,by coupling WO3-x dots-encapsulated metal-organic frameworks(MOFs)as co-reactants and terminal deoxynucleotidyl transferase(TdT)-mediated template-free branched polymerization,a dual signal-amplified electrochemiluminescent(ECL)biosensor was constructed to detect DNA adenine methylation(Dam)MTase.The employment of WO3-x dots-encapsulated MOFs(i.e.,NH2-UIO66@WO3-x)was not only beneficial for biomolecule conju-gation because of the abundant amino groups but also led to a 7-fold enhanced ECL response due to the increased loading of WO3-x.Moreover,TdT-mediated template-free branched polymerization promoted the capture of ECL emitters on the electrode surface,achieving 20-fold enhanced signal amplification.The presented ECL biosensor demonstrated a low detection limit of 2.4 × 10-4 U/mL,and displayed high reli-ability for the detection of Dam MTase in both spiked human serum and E.coli cell samples,and for the screening of potential inhibitors.This study opens a new avenue for designing a dual signal amplification-based ECL bioassay for Dam MTase and screening inhibitors in the fields of clinical diagnosis and drug development.
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    Chemoselective labeling-based spermatozoa glycan imaging reveals abnormal glycosylation in oligoasthenotspermia

    Lijia XuTong ZhongWei ZhaoBing Yao...
    475-480页
    查看更多>>摘要：Spermatogenesis,maturation,capacitation and fertilization are precisely regulated by glycosylation.How-ever,the relationship between altered glycosylation patterns and the onset and development of repro-ductive disorders is unclear,mainly limited by the lack of in situ imaging techniques for spermatozoa glycosylation.We developed an efficient and highly specific spermatozoa glycan imaging technique based on the robust chemoselective labeling of sialic acid(Sia)and N-acetyl-D-galactosamine(Gal/GalNAc).We further proposed a"tandem glycan chemoselective labeling"strategy to achieve simultaneous imaging of two types of glycans on spermatozoa.We applied the developed method to the spermatozoa from oligo-zoospermic patients and diabetic mice and found that these spermatozoa showed higher levels of Sia and Gal/GalNAc expression than the normal groups.Moreover,spermatozoa from diabetic mice showed a severe decrease in number,viability,and forward motility,suggesting that in vivo glucose metabolism disorders may lead to an elevated level of spermatozoa glycosylation and have a correlation with the development of oligoasthenotspermia.Our work provides a research tool to reveal the relationship be-tween glycosylation modification and spermatozoa quality,and a promising clue for the development of glycan-based reproductive markers.
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    Visible-light-activated aziridination reaction enables simultaneous resolving of C=C bond location and the sn-position isomers in lipids

    Qiongqiong WanYanan XiaoGuifang FengXin Dong...
    481-485页
    查看更多>>摘要：There is a close relationship between the biological functions of lipids and their structures,and vari-ous isomers greatly increases the complexity of lipid structures.The C=C bond location and sn-position are two of the essential attributes that determine the structures of unsaturated lipids.However,simul-taneous identification of both attributes remains challenging.Here,we develop a visible-light-activated aziridination reaction system,which enables the dual-resolving of the C=C bond location and sn-position isomerism of in lipids when combines with liquid chromatography-mass spectrometry(LC-MS).Based on the derivatization of C=C bonds with PhI=NTs,their location in lipids could be easily identified by tandem MS.Especially,the sn-position isomers of unsaturated phosphatidylcholine(PC)can be separated and quantified by LC-MS after the derivatization.By using the proposed method,the significant changes of the sn-position isomers ratios of PC in mouse brain ischemia were revealed.This study offers a pow-erful tool for deep lipid structural biology.
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    Nano-sized stationary phase packings retained by single-particle frit for microchip liquid chromatography

    Wangyan HuKe LiXiangnan DouNing Li...
    486-489页
    查看更多>>摘要：Modern chromatography is increasingly focused on miniaturization and integration.Compared to conven-tional liquid chromatography,microfluidic chip liquid chromatography(microchip-LC)has the potential due to its zero-dead volume connection and ease of integration.Nano-sized packings have the poten-tial to significantly enhance separation performance in microchip-LC.However,their application has been hindered by packing difficulties.This study presents a method for packing nano-sized silica particles into a microchannel as the stationary phase.The microchip-LC packed column was prepared by combining the weir and the porous silica single-particle as frit to retain the packing particles.A surface tension-based single-particle picking technique was established to insert porous single-particle frit into glass microchannels.Additionally,we developed a slurry packing method that utilizes air pressure to inject nano-sized packing into the microchannel.Pressure-driven chromatographic separation was performed using this nano-packed column integrated into a glass microchip.The mixture of four PAHs was success-fully separated within just 8 min using a 5 mm separation channel length,achieving high theoretical plates(106 plates/m).Overall,these findings demonstrate the potential of utilizing nano-sized packings for enhancing chromatographic performance in microchip systems.
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    Graphene as adsorbent for highly efficient extraction of modified nucleosides in urine prior to liquid chromatography-tandem mass spectrometry analysis

    Cheng GuoXiaoxiao ZhangXiujuan HongYiqiu Hu...
    490-495页
    查看更多>>摘要：RNA modifications have been involved in numerous biological processes,and aberrations of these mod-ifications are tightly associated with various diseases including cancer.Herein,we developed graphene-based solid-phase extraction and robust ultra performance liquid chromatography-tandem mass spec-trometry(UPLC-MS/MS)combined with stable isotope-dilution for simultaneous enrichment and accurate determination of 17 modified nucleosides in human urine.We found graphene could effectively adsorb various modified nucleosides in human urine samples.With this method,we identified and quantified these modified nucleosides in urine samples collected from lung cancer patients and healthy controls.We revealed that the levels of 12 modified nucleosides were all diminished in urine from lung cancer patients,compared with healthy controls.It is worth noting that we demonstrated,for the first time,the presence of 5,2'-O-dimethyluridine(m5Um)in human urine.Together,we established a robust analytical method for simultaneous determinations of 17 modified nucleosides in human urine,and our results re-vealed a close correlation between the concentrations of urinary modified nucleosides and the occurrence of lung cancer,implying the potential applications of these modified nucleosides as noninvasive biomark-ers for the early detection of lung cancer.Moreover,this study will stimulate future investigations on the regulatory roles of RNA modifications in the initiation and progression of lung cancer.
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    Differential bonding behaviors of sodium/potassium-ion storage in sawdust waste carbon derivatives

    Jun-Ming CaoKai-Yang ZhangJia-Lin YangZhen-Yi Gu...
    496-501页
    查看更多>>摘要：Sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs)are the most promising alternatives to lithium-ion batteries,and thus have drawn intensive research attention.Porous carbon materials from different precursors have been widely used as anode materials owing to their compatible storage effec-tiveness of both larger radii sodium and potassium ions.However,the differential bonding behaviors of Na and K ions with porous carbon-based anode are the significant one worth investigating,which could provide a clean picture of alkali ions storage mechanism.Therefore,in this work,we prepare a porous carbon network derived from sawdust(SDC)wastes,to further analyze the differences on sodium and potassium ions storage behaviors in terms of bond-forming process.It is found that,as-prepared SDC an-odes could deliver stable sodium and potassium storage capacities,however,there are notable distinctions in terms of electrochemical behaviors and diffusion processes.By virtue of ex-situ XRD and Raman spec-troscopy,the phase transition reaction of potassium ions could be well-observed,and the results shows that the multiple intercalated compounds was formed in SDC network during ions insertion,further re-sulting in slower diffusion kinetics and larger resistance compared to non-bonded process of sodium ions storage.This study provides more insights into the differences between sodium and potassium ions stor-age,as well as the energy storage mechanism of porous carbon as anodes for secondary batteries.
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    Magnetic,dielectric and luminescence synergetic switchable effects in molecular material[Et3NCH-2Cl]2[MnBr4]

    Yan ChengHua-Peng RuanYan PengLonghe Li...
    502-505页
    查看更多>>摘要：The application of multifunctional materials in various fields such as electronics and signal processors has attracted massive attention.Herein,a new organic-inorganic hybrid material[Et3NCH2CI]2[MnBr4](1)is reported,which contains two organic amines cations and one[MnBr4]tetrahedral ion.Compound 1 has a dielectric anomaly signal at 338 K,which proves its thermodynamic phase transition.The single crys-tal measurements at 200 K and 380 K show that the phase transition of compound 1 is caused by the thermal vibration of organic amine cations in the lattice.Moreover,compound 1 shows yellow-green lu-minescence under UV light irradiation.The magnetism measurements indicate that compound 1 shows switchable magnetic properties.This organic-inorganic material is a multifunctional material with di-electric,optical,and magnetic synergetic switchable effects,which expands a new direction for designing multifunctional materials.
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    Plasmon-enhanced photocatalytic oxidative coupling of amines in the air using a delicate Ag nanowire@NH2-UiO-66 core-shell nanostructures

    Yuan ZhangShenghao GongA.R.Mahammed ShaheerRong Cao...
    506-510页
    查看更多>>摘要：MOF-based core-shell structures with high surface area,abundant active sites,and broad absorption bands are viable alternatives to traditional single-component photocatalysts.In this report,we describe the design and construction of delicate Ag nanowires@NH2-UiO-66 with a core-shell structure for use as photocatalysts in imine synthesis under light.The optimized composites exhibited 80％imine pro-duction,which was higher than both MOF and Ag NWs.The significant improvement in photocatalytic activity under light may be attributed to the plasmonic effect of silver nanowires and their core-shell structure,which promotes the separation of electron-hole pairs.Moreover,the photocatalytic activity of the core-shell nanostructure may provide valuable insight into the design and construction of MOF-based composite photocatalysts for oxidative coupling of amines.
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