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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    A non-viral gene therapy for melanoma by staphylococcal enterotoxin A

    Ling YangMin RenJie WangLiming He...
    325-329页
    查看更多>>摘要：Staphylococcal enterotoxin A(SEA)derived from Staphylococcus aureus,as a superantigen,shows potential for cancer immunotherapy,but systemic immunotoxicity restricts its clinical application.Targeted delivery of SEA to tumor site provides a promising option for reducing the systemic toxicity.Here,we constructed an iRGD peptide(H-[Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys]-NH2)modified nanoparticle(iDPP)to deliver plasmids encoding SEA for melanoma treatment.The iDPP/SEA nanocomplexes efficiently mediated SEA expression in B16-F10 cells in vivo and in vitro and induced the activation of lymphocytes and maturation of murine bone marrow-derived dendritic cells(BMDCs)in vitro.In the subcutaneous B16-F10 melanoma model,the iDPP/SEA nanocomplexes could effectively enhance immune response and T lymphocytes infil-tration in tumor site after intravenous administration,thereby considerably decreased melanoma growth.Meanwhile,no obvious adverse effect was observed after intravenous administration of the iDPP/SEA nanocomplexes in vivo.Our findings demonstrated that gene therapy of SEA is a potential candidate for melanoma treatment.
      原文链接:
    • 万方数据
    • 维普

    Toeless and reversible DNA strand displacement based on Hoogsteen-bond triplex

    Yang QinJiangtian LiXuehao ZhangKaixuan Wan...
    330-337页
    查看更多>>摘要：Strand displacement reaction is a crucial component in the assembly of diverse DNA-based nanodevices,with the toehold-mediated strand displacement reaction representing the prevailing strategy.However,the single-stranded Watson-Crick sticky region that serves as the trigger for strand displacement can also cause leakage reactions by introducing crosstalk in complex DNA circuits.Here,we proposed the toeless and reversible DNA strand displacement reaction based on the Hoogsteen-bond triplex,which is compat-ible with most of the existing DNA circuits.We demonstrated that our proposed reaction can occur at pH 5 and can be reversed at pH 9.We also observed an approximately linear relationship between the degree of reaction and pH within the range of pH 5-6,providing the potential for precise regulation of the reaction.Meanwhile,by altering the sequence orientation,we have demonstrated that our proposed reaction can be initiated or regulated through the same toeless mechanism without the requirement for protonation in low pH conditions.Based on the proposed reaction principle,we further constructed a variety of DNA nanodevices,including two types of DNA logic gates that rely on pH 5/pH 9 changes for initiating and reversing:the AND gate and the OR gate.We also successfully constructed a DNA Walker based on our proposed reaction modes,which can move along a given track after the introduction of a programmable DNA sequence and complete a cycle after 4 steps.Our findings suggest that this innova-tive approach will have broad utility in the development of DNA circuits,molecular sensors,and other complex biological systems.
      原文链接:
    • 万方数据
    • 维普

    Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death

    Kun-Heng LiHong-Yang ZhaoDan-Dan WangMing-Hui Qi...
    338-343页
    查看更多>>摘要：AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)inducers.To date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregation-induced emission(AIE)molecules have been developed and have evoked massive ICD in cells.However,due to the complex physicochemical environment in cells,these small AIE molecules cannot maintain a stable aggregate state,which not only affects the fluorescence intensity of the photosensitizer but also decreases the generation of reactive oxygen species(ROS),and thus reducing the effect of the photo-sensitizer to elicit ICD.AIEgen-based nanomicelles,which maintain a stable micellar structure,can pre-vent defects of AIE molecules in photodynamic therapy(PDT)applications.Therefore,in this study,a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highly potent ICD inducer for vaccine preparation and tumor prevention.
      原文链接:
    • 万方数据
    • 维普

    Mitochondria-targeted nanoparticles overcome chemoresistance via downregulating BACH1/CD47 axis in ovarian carcinoma

    Ke GongJinghan LiaoJiangtao LinQuan Wang...
    344-350页
    查看更多>>摘要：The platinum-based chemotherapy is a routine strategy for the treatment of ovarian cancer,while it is prone to chemoresistance in clinical,which hinders the treatment.Therefore,it is urgently needed to elucidate the underlying mechanism of drug resistance and form the appropriate strategy.The sequenc-ing results showed that cisplatin(DDP)resistant ovarian cancer overexpressed BTB and CNC homology 1(BACH1),and up-regulated the"don't eat me"signal CD47.We identified that hemin,a BACH1 in-hibitor,could effectively down-regulate BACH1 and simultaneously inhibit CD47.Moreover,hemin has a synergistic effect with DDP.We designed a pH-responsive nanoparticle(H/D@FA-CaP-NPs)in which folic acid(FA)ensured targeting of ovarian cancer cells,while hemin inhibited BACH1 as well as down-regulated CD47,achieving the promotion of apoptosis of tumor cells and inducing phagocytosis of tumors by macrophages.Moreover,hemin has a synergistic effect with DDP to promote apoptosis of tumor cells.Structurally,hemin and DDP was encapsulated within hydrophobic 1,2-distearoyl-sn-glycero-3-phospho-ethanolamine(DSPE)to form a tight core,and hydrophilic polyethylene glycol 2000(PEG2000)and cal-cium phosphate(CaP)formed the outside shell,and FA was modified on the surface of nanoparticles.In terms of function,(a)FA enhanced the active targeting of nanoparticles to tumors;(b)NPs targeted mi-tochondria to induce reactive oxygen species(ROS)production;(c)hemin encapsulated in nanoparticles could specifically target BACH1,thereby down regulating CD47;(d)hemin had a synergistic effect with DDP,thus augmenting the chemotherapy.Altogether,mitochondria-targeted nanoparticles H/D@FA-CaP-NPs promoted tumor apoptosis and mobilized phagocytosis to treat tumor,providing a novel scheme for clinical treatment of cisplatin-resistant ovarian carcinoma.
      原文链接:
    • 万方数据
    • 维普

    Direct detection of C9orf72 hexanucleotide repeat expansions by nanopore biosensor

    Xinqiong LiGuocheng RaoXi PengChan Yang...
    351-354页
    查看更多>>摘要：Diagnostic C9orf72 hexanucleotide repeat expansions(C9-HRE)is essential for the early and accurate di-agnosis of amyotrophic lateral sclerosis(ALS)and will provide support for the prognosis and gene therapy of ALS.In the present study,by combining catalytic hairpin assembly(CHA)with Mycobacterium smegma-tis porin A(MspA)nanopore,a new nanopore-based strategy for the detection of C9-HRE was reported.Less than 30 repeats of C9-HRE could be detected via this method,and the results have the potential to help distinguish between patients and healthy individuals.Moreover,the method demonstrated its great specificity for C9-HRE by identifying other repeat expansions.Given the high selectivity,this approach had been successfully used to detect C9-HRE in cell and blood samples with high accuracy.This detec-tion strategy is user-friendly and has a strong anti-interference ability,thus providing a powerful tool for clinical diagnosis.
      原文链接:
    • 万方数据
    • 维普

    NOx reduction against alkali poisoning over Ce(SO4)2-V2O5/TiO2 catalysts by constructing the Ce4+-SO42-pair sites

    Shuangxi LiHuijun YuTianwei LanLiyi Shi...
    355-360页
    查看更多>>摘要：Commercial V2O5-based catalysts have been successfully applied in NH3 selective catalytic reduction(NH3-SCR)of NOx from power stations,but their poor alkali-resistance restrains the wider application in nonelectrical industries.In this study,NOx reduction against alkali poisoning over V2O5/TiO2 is greatly improved via Ce(SO4)2 modification.It has been originally demonstrated that Ce4+-SO42-pair sites play crucial roles in improving NOx reduction against alkali poisoning over V2O5/TiO2 catalysts.The strong in-teraction between V species and Ce sites of Ce4+-SO42-pairs triggers the reaction between NH4+species and gaseous NO via Eley-Rideal(E-R)reaction pathway.After K-poisoning,the SO42-sites of Ce4+-SO42-pairs as protective sites strongly bond with K and thus maintain the high reaction efficiency via the E-R reaction pathway.This work demonstrates an effective strategy to enhance NOx reduction against alkali poisoning over catalysts via constructing Ce4+-SO42-pair sites,contributing to developing alkali-resistant SCR catalysts for practical application in nonelectrical industries.
      原文链接:
    • 万方数据

    Highly efficient capture of thorium ion by citric acid-modified chitosan gels from aqueous solution

    Linshan PengQihang PengTianxiang JinZhirong Liu...
    361-365页
    查看更多>>摘要：A novel citric acid-modified chitosan gel(CSCA)was synthesized through a simple one-step process and was used to extract thorium ions from wastewater.The CSCA samples with varying chemical composi-tions were analyzed using SEM with mapping EDS,FT-IR,and static water contact angle measurements,and their adsorption behaviors were studied in detail.The results showed that the adsorption perfor-mance of CSCA improves with the increase of CA content in the sample.CSCA possesses an impressive capacity for thorium adsorption of 279.8 mg/g.Furthermore,it showed an ultra-fast adsorption rate and reached equilibrium within 30 min.In terms of recyclability,the CSCA still retained more than 86％of its initial adsorption capacity after 6 cycles of reuse.Density functional theory(DFT)analysis reveals that the good selectivity of this material towards thorium ions should be attributed to the high density of adsorption sites and strong interaction between carboxyl groups and thorium ions.This work could be beneficial in the design and synthesis of new polymer materials for extracting thorium.
      原文链接:
    • 万方数据
    • 维普

    A nonradical oxidation process initiated by Ti-peroxo complex showed high specificity toward the degradation of tetracycline antibiotics

    Jian PengYue JiangShuangyu WuYanran Cheng...
    366-370页
    查看更多>>摘要：Nonradical oxidation has received wide attention in advanced oxidation processes for environmental re-mediation.Understanding the relationship between material characteristics and their ability to initiate nonradical oxidation processes is the key to better material design and performance.Herein,a novel titanium-based metal-organic framework MIL-125-Ti/H2O2 system was established to show a highly selec-tive degradation efficacy toward tetracycline antibiotics.MIL-125-Ti with the abundance of TiO6 octahedra units was found to effectively activate H2O2 under dark conditions by forming an oxidative Ti-peroxo complex.The presence of the Ti-peroxo complex,confirmed by UV-visible spectrophotometer,fourier transform infrared spectroscopy,and X-ray photoelectron spectroscopy characterizations,showed supe-rior degradation(＞95％removal rate)of oxytetracycline hydrochloride(OTC),doxycycline hydrochloride,chlortetracycline hydrochloride,and tetracycline.Density functional theory calculations were performed to assist the elucidation on the mechanism of H2O2 activation and antibiotics degradation.The MIL-125-Ti/H2O2 system was highly resistant to halogens and background organics,and could well maintain its original catalytic activity in actual water matrices.It retained the ability to degrade 75％of OTC within ten test cycles.This study provides new insight into the nonradical oxidation process initiated by the unique Ti-peroxo complex of Ti-based MOF.
      原文链接:
    • 万方数据
    • 维普

    Effective peroxydisulfate activation by CQDs-MnFe2O4@ZIF-8 catalyst for complementary degradation of bisphenol A by free radicals and non-radical pathways

    Shuo LiXinran LiuYongjie ZhengJun Ma...
    371-379页
    查看更多>>摘要：The present study reported fabrication of novel carbon quantum dots-MnFe2O4@ZIF-8(CQDs-MFO@ZIF-8)by using co-precipitation hydrothermal method for activation of peroxydisulfate(PDS)to degrade bisphenol A(BPA),one of important emerging organic pollutants in water environment.CQDs-MFO@ZIF-8 served as a highly efficient thermal activated PDS catalyst with high catalytic degradation efficiency,reusability and stability.The catalyst achieved almost completely removal of 20.0 mg/L BPA within 5.0 min,and the degradation efficiency remained higher than 83％after 5 consecutive cycles.Free radicals(·OH,SO4·-and·O2-)and non-free radicals(1O2)were generated in the thermal PDS-activation system,in which singlet oxygen(1O2)played a dominant role in the degradation of BPA.The potential toxicity of BPA degradation intermediates was analyzed upon the culture of E.coli and Chlorella sorokiniana by using Ecological Structure-Activity Relationship Model(ECOSAR)program.The catalytic performances of BPA degradation by CQDs-MFO@ZIF-8 were evaluated for treatment of different practical water samples to further verify the feasibility of practical applications.This study provides proof-in-concept demonstration of new nanomaterials for enhanced catalytic water decontamination.
      原文链接:
    • 万方数据

    Removal of Microcystin-LR in lake water sample by hydrophilic mesoporous silica composites under high-throughput MALDI-TOF MS detection platform

    Wantong ZhangZixing XuGuofei DaiZhijian Li...
    380-385页
    查看更多>>摘要：Microcystins(MCs),a family of cyclic heptapeptide cyanotoxins,exists in aquatic environment where cyanobacterial bloom happens,which will accumulate in aquatic organisms and transfer through the food chain to higher trophic levels,posing a health risk to both animals and human bodies.Among var-ious MCs,Microcystin-LR(MC-LR)is worthiest studied for its strong toxicity,ubiquity and widespread.Here in this work,iminodiacetic acid(IDA)decorated magnetic mesoporous silica(mSiO2)nanocom-posites(Fe3O4@mSiO2-IDA)were facilely synthesized which possessed the merits of large surface area(188.21 m2/g),accessible porosity(2.66 nm),excellent hydrophilicity and rapid responsiveness to mag-netic field.Then the composites were successfully employed to the removal process of Microcystin-LR in real water samples followed by Matrix-assisted laser desorption/ionization time-of-flight mass spectrom-etry(MALDI-TOF MS)analysis,achieving the removal efficiency above 92.5％even after ten recycles of the composites.It provided a potential method for removing MC-LR in aqueous environment with high effectiveness,lower costs and less secondary contamination.
      原文链接:
    • 万方数据
    • 维普