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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition

    Chenlu HuangXinyu YangQingyu YuLinhua Zhang...
    456-461页
    查看更多>>摘要：Due to the heterogeneity of tumors,single phototherapy cannot completely ablate tumors and inhibit tu-mor metastasis.To overcome these,we formulated targeted and multifunctional polymersomes ABC@ICG-IMQ-LHRH(AIRL)that encapsulated Toll-like receptor(TLR)7/8 agonist imiquimod(IMQ)and photosen-sitizer indocyanine green(ICG)in the hydrophobic layer as well as bubble-generator NH4HCO3 in the hydrophilic cavity to inhibit the growth of primary and distant tumors,and prevent tumor metastasis through synergistic photoimmunotherapy.The AIRL polymersomes exhibited uniform and stable size,and high drug encapsulation efficiency,acid/reduction/laser responsiveness,excellent photothermal conver-sion efficiency,effective reactive oxygen species generation,high tumor accumulation.AIRL could be ef-fectively internalized by dendritic cells(DCs),achieve lysosome escape and enhance DCs maturation.The synergistic photoimmunotherapy via AIRL polymersomes remarkably promoted the differentiation and activation of T cells,elevated strong systemic immune response to eradicate primary tumors and inhibit the growth of distant tumors.Simultaneously,the endurable immunological memory prevented tumor metastasis,which provided a promising nanoplatform for the combination therapy of cancer.
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    Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of SZ-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis

    Yu YanJiawei SongDongdong LiuZihan Liu...
    462-468页
    查看更多>>摘要：Ulcerative colitis(UC)is a chronic inflammatory bowel disease characterized by persistent inflamma-tion of the colon and disrupted intestinal function.Ramulus mori(Sangzhi)alkaloids(SZ-A),derived from twigs of mulberry,were approved by the National Medical Products Administration in 2020 for treat-ing type 2 diabetes mellitus.Accumulated evidence has confirmed that SZ-A also alleviates non-alcoholic fatty liver disease and ameliorates inflammation,indicating its potential to address inflammation in UC.However,the treatment of UC faces challenges due to low drug delivery efficiency and short retention time.To overcome these challenges,an injectable and adherent in-situ thermo-sensitive hydrogel contain-ing SZ-A was developed for rectal drug delivery,utilizing the thermo-sensitive polymers Poloxamer 407 and 188.The thermo-sensitive hydrogel system was designed with a moderate gelation temperature of 32±0.5 ℃,a short gelation time of 64 s,a pH range of 7-10,high moisturizing capability exceeding 90％,and moderate mechanical strength of 4-5 s.In a rat model with UC,the in situ thermo-sensitive hydro-gel significantly extended the retention time at the colonic site and enabled sustained release after rectal administration.Symptoms of UC were markedly reduced following rectal administration of SZ-A thermo-sensitive hydrogel.Furthermore,the release of inflammatory factors,such as interleukin-1β(IL-1β),IL-6,IL-18,tumor necrosis factor-α(TNF-α),and transforming growth factor-β1(TGF-β1),significantly de-creased in the SZ-A thermo-sensitive hydrogel group.The integrity of the colonic mucosal barrier was significantly enhanced following the application of SZ-A thermo-sensitive hydrogel.In conclusion,rectal administration of SZ-A in situ thermo-sensitive hydrogel effectively alleviated UC symptoms,inhibited the secretion of inflammatory factors,and promoted the repair of the colonic mucosal barrier.This approach holds promise as a potential treatment for UC.
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    Reinterpret the heterogeneous reaction of α-Fe2O3 and NO2 with 2D-COS:The role of SDS,UV and SO2

    Haojie DuanHejingying NiuLina GanXiaodi Duan...
    469-473页
    查看更多>>摘要：Heterogeneous reaction of mineral aerosols and atmospheric polluting gases play an important role in atmospheric chemistry.In this study,the reactions of NO2 with or without SO2 mixture gas on the sur-face of α-Fe2O3 particles under dry conditions were studied.The effects of sodium dodecyl sulfate(SDS)and the heterogeneous reaction under both dark and UV irradiation conditions were investigated.The in-frared spectrum analyzed by the two-dimensional correlation spectroscopy(2D-COS)was used to obtain the products formation sequences.The results showed that UV irradiation can promote the production of nitrate.The 2D-COS analysis indicated SDS changed the sequence order of nitrate and nitrite species during reactions.In oxidation conditions,the final product of heterogeneous reaction of NO2 and α-Fe2O3 was monodentate nitrate.Only the heterogenous reaction of NO2 and α-Fe2O3 containing SDS(FOS)with-out UV light,the final product was bidentate nitrate.SDS was the catalysis agent supply and photoresist to the system.With surface active compounds,the environmental lifetime of heterogeneous reactions be-tween trace gases and aerosols extends.Surfactants,ultraviolet light,and the types of gases involved in the reaction all have complex effects on the aerosol aging process.This study provided a reference for subsequent heterogeneous reaction studies and the formation of aerosols.
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    Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine?Autophagy regulation also works

    Yuanyi ZhouKe MaJinfeng LiuZirun Zheng...
    474-479页
    查看更多>>摘要：Exploring the therapeutic effect of single atom catalysts beyond reactive oxygen species(ROS)modu-lation would boost the prosperity of nanomedicine in cancer treatment.Autophagy as a vital therapy target offers new options for the control of renal cell carcinoma(RCC)progression.Herein,Fe single atom-decorated graphene oxide(Fe1-GO)nanosheet is developed to be a feasible autophagy inducer in RCC treatment.With the well-dispersed O-Fe1-O active sites,Fe1-GO kills ACHN cells effectively but maintains acceptable cytotoxicity to the normal podocyte and HK2 ones.In-depth analyses ascribe the inhibition of ACHN cells to the upregulated autophagy instead of the commonly known catalytic ROS generation.The in vivo therapeutic effect of Fe1-GO nanomedicine is also validated by the RCC-bearing BALB/c mice model,realizing an 89％reduction of tumor weight and good biosafety.This work provides new insights into the design of autophagy regulators as well as potential therapeutic strategies for RCC treatment.
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    Tuning the membrane rejection behavior by surface wettability engineering for an effective water-in-oil emulsion separation

    Yan ZouYin-Shuang HuDeng-Hui TianHong Wu...
    480-485页
    查看更多>>摘要：Membrane-based separation is a promising technology to eliminate water impurities from the oil phase.However,it remains a great challenge to separate water from highly emulsified viscous oil owing to the high stability of the water droplets in oil.Herein we report a surface wettability engineering on an alu-mina ceramic membrane to achieve an efficient separation of a water-in-oil(W/O)emulsion.Silanes with different carbon chain lengths and fluorinated status were introduced to endow the alumina membrane with different surface wettabilities.While all the modified membranes exhibited excellent separation of the W/O without Span 80(surfactant),the one with amphiphobic wettability and lowest surface energy failed to separate the Span 80 stabilized W/O.The presence of Span 80 reduced the interfacial tension of water droplets,making them easier to deform and penetrate the modified membrane with the lowest surface energy.It reveals that engineering proper surface wettability is the key to separating the oil and water phases.Besides,the modified membranes maintained decent separation performance and stability under long-term run separation of the emulsified W/O.
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    4-Nitrocatechol as a novel matrix for low-molecular-weight compounds in situ detection and imaging in biological tissues by MALDI-MSI

    Hualei XuManman HanHaiqiang LiuLiang Qin...
    486-490页
    查看更多>>摘要：Low-molecular-weight(LMW)compounds are ubiquitous in living organisms and play essential roles in biological processes.The direct analysis of LMW compounds in biological tissues by matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI)could provide a more comprehensive un-derstanding of their essential functions.Here,we evaluated 4-nitrocatechol(4-NC)as a novel positive-ion matrix for enhancing in situ detection and imaging of LMW compounds from the rat liver,brain,and germinating Chinese-yew seed by MALD1-MS.Our results showed that the 4-NC possessed remarkable features,including strong ultraviolet absorption,uniform matrix crystal,excellent chemical stability,and fewer matrix-related background peaks.The use of 4-NC led to the successful detection of 232,218,and 193 LMW compounds from the three abovementioned tissue sections,respectively.Also,the use of 4-NC improved the imaging quality of LMW compounds in tissue sections through MALDI-MSI and has the potential as a matrix for MALDI tissue imaging of LMW compounds.
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    The Mn/Yb/Er triple-doped CeO2 nanozyme with enhanced oxidase-like activity for highly sensitive ratiometric detection of nitrite

    Simin WeiYaqing YangJunjie LiJialin Wang...
    491-495页
    查看更多>>摘要：Long-term excessive intake of nitrite(NO2-)poses a great threat to human health,needing a simple and fast method to detect NO2-in food.Herein,via a simple and feasible strategy,Mn/Yb/Er triple-doped CeO2 nanozyme(Mn/Yb/Er/CeO2)was synthesized for highly sensitive ratiometric detection of nitrite.By doping Mn,Yb,Er into CeO2 lattice structure,Mn/Yb/Er/CeO2 nanozyme showed enhanced oxidase-like activity,obtaining a higher density of oxygen vacancy and a higher ratio of Ce3+to Ce4+than that of CeO2.The 3,3',5,5'-tetramethylbenzidine(TMB)can be effectively oxidized by Mn/Yb/Er/CeO2 to produce the oxidized TMB(oxTMB),showing a significant absorption signal at 652 nm.Additionally,nitrite can react with oxTMB to produce yellow diazotized oxTMB,which is accompanied by an elevated absorp-tion signal at 445 nm and a decreased absorption signal at 652 nm.Thus,based on the oxidase-mimetic activity of Mn/Yb/Er/CeO2 and the diazotization reaction between NO2-and oxTMB,a ratiometric col-orimetric assay was established for NO2-detection in food.Furthermore,by integrating Mn/Yb/Er/CeO2 with a smartphone,a colorimetric smartphone-sensing platform was successfully fabricated for visualiza-tion and quantitative detection of NO2-.Notably,this two-detection mode showed excellent sensitivity,selectivity,reliability and practicability in monitoring the NO2-in real samples,impling its great potential for food safety.
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    Supramolecular phenolic network-engineered C-CeO2 nanofibers for simultaneous determination of isoniazid and hydrazine in biological fluids

    Gang LangJing FengBo FengJunlan Hu...
    496-501页
    查看更多>>摘要：Electrochemical sensing provides a powerful technological means for the therapeutic drug monitoring of drug-resistant tuberculosis but requires a functionalized electrode to capture the analytes and catalyze their redox reactions.Herein,we construct a nickel-tannic acid supramolecular network(Ni-TA)on the surface of electrospun-derived C-CeO2 nanofiber for the sensitive and simultaneous detection of isoni-azid(INZ)and hydrazine(HYD).Mechanistic investigations demonstrate that Ni-TA is electronegative and hydrophilic,thus facilitating an efficient mass and electron transfer.Ni-TA/C-CeO2 has higher adsorption rate constants(0.091 g mg-1 h-1 for INZ,and 0.062 g mg-1 h-1 for HYD)than native C-CeO2(0.075 g mg-1 h-1 for INZ,and 0.047 g mg-1 h-1 for HYD).Moreover,Ni-TA/C-CeO2(56 Ω)has lower charge transfer re-sistances than C-CeO2(417 Ω).Ni-TA/C-CeO2 performs low detection limits and wide linearity ranges for INZ(0.012 μmol/L and 0.1-400 μmol/L,respectively)and HYD(0.008 μmol/L and 0.015-1420 μmol/L,respectively),coupled with high selectivity,cycle stability and reproducibility.This research demonstrated the promising applications of Ni-TA/C-CeO2 by analyzing human-collected plasma and urine samples.
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    First-principles study of the relationship between the formation of single atom catalysts and lattice thermal conductivity

    Chaozheng HePei ShiDonglin PangZhanying Zhang...
    502-506页
    查看更多>>摘要：Single atom catalysts(SACs)have been in the forefront of catalysts research because of their high effi-ciency and low cost and provide new ideas for development of renewable energy conversion and storage technologies.However,the relationship between the intrinsic properties of materials such as lattice ther-mal conductivity and catalysis remains to be explored.In this work,the lattice thermal conductivity of BN and graphene was calculated by ShengBTE.In addition,the adsorption properties of 3d-TM(TM=V,Cr,Mn,Fe,Co,Ni)on BN and graphene were investigated using first-principles methods,and it was found that Ni atom can form relatively stable SACs compared to other TMs.The molecular dynamics(MD)sim-ulation and migration barrier of Ni loaded on BN and graphene were calculated.Our study found that graphene has higher thermal conductivity and is easier to form SACs than BN,but the SACs formed on BN surface have higher thermodynamic stability.
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    Enhanced interfacial charge transfer on Bi metal@defective Bi2Sn2O7 quantum dots towards improved full-spectrum photocatalysis:A combined experimental and theoretical investigation

    Huizhong WuRuiheng LiangGe SongZhongzheng Hu...
    507-514页
    查看更多>>摘要：To mitigate the water pollution problem by photocatalytic degradation of typical antibiotics of tetracycline(TC),we prepared defective Bi2Sn2O7(BSO)quantum dots(QDs)with a full spectral response due to Bi metal deposition,using a one-pot hydrothermal method,labeled as Bi@BSO-OV.The optimized Bi@BSO-OV showed 73.4％removal of TC in 1 h under irradiation with a 50 W LED lamp in the wavelength band in the visible-near-infrared(vis-NIR)light,a rate that is substantially greater than that of pure BSO(14.7％).The synergistic interaction of Bi metal and oxygen vacancies(OVs)is crucial to boosting photocatalytic performance.The near-infrared region of the photo-response is extended by the surface plasmon resonance(SPR)effect of Bi metal,enhancing the photocatalytic performance and dramatically raising the efficiency of solar energy utilization.In addition to inducing defect levels in BSO,the OVs also activate the surface adsorbed O2 to promote the production of·O2-and 1O2.DFT calculations reveal that Bi metal and OVs can mutually tune the charge transfer pathways.On the one hand,Bi metal can act as both a charge transfer bridge and an electron donor to assist charge separation.On the other hand,OVs-induced defect levels allow electrons that leap to the conduction band(CB)to first leap from the valence band(VB)to the defect levels,notably improving interfacial charge separation and transfer.The concept of design executed in this study for altering the catalyst by introducing both OVs and Bi metal can provide a rational design idea and potential insight for improving the photocatalytic activity for environmental applications.
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