首页期刊导航|中国化学快报（英文版）
期刊信息/Journal information
中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
正式出版
收录年代

    Nitrite-catalyzed economic and sustainable bromocyclization of tryptamines/tryptophols to access hexahydropyrrolo[2,3-b]indoles/tetrahydrofuroindolines in batch and flow

    Xiao XiaoBiao ChenJia-Wei LiJun-Bo Zheng...
    247-252页
    查看更多>>摘要：A highly efficient and concise bromocyclization has been successfully achieved,in which tryptamine/tryptophol derivates can be transformed to valuable HPI/TFI scaffolds with economic and green manners.Moreover,a controllable cascade transformation of bromocyclization and aromatic bromination has also been smoothly achieved to form dibrominated HPIs and TFIs.Production could be successfully scaled up under both the batch process and a continuous flow fashion.The most remarkable peculiarity of our process over all previous methods is that the generated water is the major waste.Notably,successful application of this new protocol has been demonstrated by the pharmaceutical and natural products syntheses.
      原文链接:
    • 万方数据
    • 维普

    Cobalt-catalyzed reductive alkynylation to construct C(sp)-C(sp3)and C(sp)-C(sp2)bonds

    Lei WanYizhou TongXi LuYao Fu...
    253-258页
    查看更多>>摘要：Transition-metal-catalyzed cross-electrophile coupling has emerged as a reliable method for constructing carbon-carbon bonds.Herein,we report a general method,cobalt-catalyzed reductive alkynylation,to construct C(sp)-C(sp3)and C(sp)-C(sp2)bonds.This presented reaction has a broad substrate scope,enabling the efficient cross-electrophile coupling between alkynyl bromides with alkyl halides and aryl or alkenyl(pseudo)halides.This presented reaction is conducted under mild conditions,tolerating many functional groups,thus suitable for the modification and synthesis of biologically active molecules.
      原文链接:
    • 万方数据

    Synthesis and reactivity of cobalt dinitrogen complex supported by nonsymmetrical pincer ligand

    Yuanjin ChenXianghui ShiDajiang HuangJunnian Wei...
    259-263页
    查看更多>>摘要：A nonsymmetrical PNN pincer ligand[6-(tBu2PNH)C5H4N-2-(3-Mes)C3H2N2]and its corresponding cobalt-N2 complex were synthesized and characterized.By the stoichiometric reaction of the PNN lig-and lithium salt with CoCl2,the complex 3,(PNN)CoCl,was obtained.Then,reduction of 3 with NaBHEt3 under a dinitrogen atmosphere yielded complex 5,(PNN)Co(Ⅰ)(η 1-N2).Single-crystal X-ray analysis,IR spectrum,and DFT calculations revealed that the dinitrogen in 5 was only weakly reduced by the cobalt center.The reactions of 5 with carbon monoxide and 2,6-dimethylphenyl isocyanide gave carbonyl and isocyanide complexes 6 and 7 with the release of N2,respectively.Furthermore,these cobalt complexes,especially complex 5,demonstrated the capacity to convert dinitrogen to N(TMS)3 with moderate effi-ciency.
      原文链接:
    • 万方数据
    • 维普

    Copper(Ⅰ)-catalyzed diastereodivergent construction of vicinal P-chiral and C-chiral centers facilitated by dual"soft-soft"interaction

    Yan-Bo LiYi LiLiang Yin
    264-270页
    查看更多>>摘要：A copper(Ⅰ)-catalyzed diastereodivergent addition of phosphinothioates(HP(S)ROR')to α,β-unsaturated thioamides is disclosed,which constructs vicinal P-chiral and C-chiral centers in generally high diastereo-and enantioselectivities.In this reaction,the kinetic resolution of HP(S)ROR'occurs,which affords(R)-HP(S)PhOMe in high enantioselectivity in the addition with(R,R)-Ph-BPE as the ligand.It is found through control experiment that dual"soft-soft"interaction,indicated by both 1H and 31P NMR experiments,is indispensable in the present reaction.The first"soft-soft"interaction between copper(I)catalyst and HP(S)ROR'enables facile deprotonation to generate nucleophilic[Cu]-SPROR'species.The second one be-tween the[Cu]-SPROR'species and α,β-unsaturated thioamides facilitated the nucleophilic addition.Fi-nally,both Michael adducts and(R)-HP(S)PhOMe are easily converted to synthetically useful compounds.
      原文链接:
    • 万方数据

    Highly selective α-C(sp3)-H arylation of alkenyl amides via nickel chain-walking catalysis

    Haoran ShiJiaxin WangYuqin ZhuHongyang Li...
    271-275页
    查看更多>>摘要：Herein,we report the migratory hydroarylation of unactivated alkenes with aryl iodides using native and weakly coordinating amide directors under mild conditions.Synergistic coordination of the monoden-tate directing group and the ligand enable the highly regioselective migratory hydroarylation via a chain walking process to form the thermodynamically stable five-membered nickelacyle intermediate.The pro-tocol provides a variety of valuable α-aryl-substituted alkylamine products,and exhibited good functional group tolerance.The modification of bioactive compounds such as fenofibrate and indomethacin further highlights the synthetic value of this protocol.
      原文链接:
    • 万方数据

    Base-controlled NHC-Ru-catalyzed transfer hydrogenation and α-methylation/transfer hydrogenation of ketones using methanol

    Ming HuangXiuju CaiYan LiuZhuofeng Ke...
    276-280页
    查看更多>>摘要：Herein,we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with methanol.By simply changing the base,a broad range of structurally diverse ketones,could be se-lectively and efficiently converted to the corresponding β-methylated secondary alcohols or secondary alcohols.Remarkably,this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols,as well as the three-component coupling between methyl ketones,primary al-cohols,and methanol.The reaction mechanism was further revealed by experiment and DFT mechanistic investigations.
      原文链接:
    • 万方数据

    Visible-light photoredox-catalyzed carboxylation of aryl epoxides with CO2

    Tian-Yu GaoXiao-Yan MoShu-Rong ZhangYuan-Xu Jiang...
    281-284页
    查看更多>>摘要：Herein,we report the first visible-light photoredox-catalyzed carboxylation of aryl epoxides with CO2 to synthesize hydroxy acid derivatives.A variety of valuable β-,γ-,δ-,ε-hydroxy acid derivatives are obtained in moderate to high yields under mild conditions.This protocol shows noteworthy functional-group compatibility,high chemo-and regioselectivities under transition-metal-free conditions with an inexpensive organo-dye as photosensitizer.Mechanistic studies indicate that the benzylic carbanion is generated as an intermediate via the sequential single electron transfer(SSET)process.
      原文链接:
    • 万方数据

    Evolution of hollow nanosphere to microtube in the self-assembly of chiral dansyl derivatives and inversed circularly polarized luminescence

    Sifan DuYuan WangFulin WangTianyu Wang...
    285-290页
    查看更多>>摘要：Here,we designed asymmetric(mDS)and symmetrical(dDS)chiral V-shaped molecules by linking one or two dansyl groups to trans-1,2-cyclohexane diamine and investigated the solvent-regulated struc-tural transformation and inversed circularly polarized luminescence(CPL)in the self-assemblies.Upon increasing water volume fraction(fw)in the mixed solvent of water/acetonitrile,asymmetric mDS self-assembled into hollow nanospheres and microtubes,while solid nanospheres and solid microplates were corresponding to symmetric dDS.During this transformation process,the emission of mDS and dDS was changed from yellow-green to blue and cyan color,which was ascribed to twisted intramolecular charge transfer(TICT)and locally excited(LE)fluorescence of V-shaped DS molecules.The conformation of N,N-dimethyl groups with respect to naphthalene ring also led to the transformation of structures.These tubular and platelike structures had stronger and reversed CPL signals in comparison with spheroidal structures.The chiral information of DS assembly could be effective transferred to achiral Nile red via co-assembly strategy,which endowed Nile red exhibiting inversed induced CPL signal regulated by water fraction.This work provides a method for achieving a variety of self-assembled structures with adjustable chiroptical properties.
      原文链接:
    • 万方数据
    • 维普

    A novel fused bi-macrocyclic host for sensitive detection of Cr2O72-based on enrichment effect

    Ting-Ting HuangJin-Fa ChenJuan LiuTai-Bao Wei...
    291-295页
    查看更多>>摘要：Improving the highly selective and sensitive binding of chemosensor to target guest is always very chal-lenging.In order to solve this issue,herein,the enrichment effect was introduced into the design of chemosensor molecule.A novel bi-fused-macrocyclic host molecule BPN1 was synthesized by bridging a pillar[5]arene and a naphthalene diimide(NDI)group through hydrogen-bond-rich chain.In the BPN1,the naphthalimide side ring is outside the cavity of the pillar[5]arene.In addition,Cr(Ⅵ)greatly threat human health and the environment due to its severe toxicity,and it is very important to develop effec-tive chemosensor for sensitive and selective detection of Cr2O72-or its ion pairs.In this paper,the novel bi-fused-macrocyclic host molecule BPN1 can recognize Cr2O72-with high selectivity and sensitivity.The mechanism of BPN1 recognition of Cr2O72-was studied through experiments and density functional the-ory(DFT),the results show that BPN1 could supply enrichment effect to bind Cr2O72-through multiple weak interactions such as hydrogen bonds and anion-π,and achieve highly sensitive and selective detec-tion of Cr2O72-.It is a significant and feasible strategy for improve high selectivity and sensitivity of host to specific objects by using the enrichment effect of fused bi-macrocyclic.
      原文链接:
    • 万方数据

    Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy

    Wenjuan JinZelong ChenYi WangJiaxuan Li...
    296-300页
    查看更多>>摘要：Chemodynamic therapy(CDT)combined with dual phototherapy(photothermal therapy(PTT)and pho-todynamic therapy(PDT))is an efficient way to synergistically improve anti-tumor efficacy.However,the combination of multiple modes often makes the composition of the system more complex,which is not conducive to clinical application.In this study,a dual phototherapy ligand carboxyl-modified Aza-BODIPY(BOD-COOH)and metal active center Cu2+were used to construct multiple-modes metal-photosensitizer nanoparticles(BOD-Cu NPs)via one-step coordination self-assembly for combination ther-apy of CDT/PDT/PTT.In order to improve delivery efficiency,the targeted hydrophilic molecule pyridine-modified glucose derivative(G-Py)was synthesized and coated onto the BOD-Cu NPs to form a glyco-sylated nano metal-photosensitizer BOD-Cu@G by electrostatic interaction.The Cu2+in BOD-Cu@G could not only be used as a coordination node for metal-driven self-assembly but also consume intracellular glutathione(GSH),and then catalyze Fenton-like reaction to generate hydroxyl radical(·OH)for CDT.In vitro and in vivo studies revealed that BOD-Cu@G could achieve excellent anti-tumor efficiency by CDT-enhanced dual phototherapy.
      原文链接:
    • 万方数据
    • 维普