查看更多>>摘要：? 2022Fifteen compounds, including five new phorbol esters (1-5) and ten known metabolites were isolated from the leaves of Croton tiglium. The structures of new compounds 1-5 were determined by comprehensive analysis of the HRESIMS, IR, 1D and 2D NMR spectral data. The isolates were assayed for their larvicidal and α-glucosidase inhibitory activity; results suggested the new compounds 1-4 possessed significant insecticidal activity, inhibiting the Plutella xylostella with LC50 values ranging from 0.081 to 0.114 μg/mL, while the sesquiterpenoids 11 and 15 showed noticeable α-glucosidase inhibitory activity with IC50 values of 11.27 and 8.13 μM, respectively.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo new compounds named cleroserroside C (1), schisphenlignan O (2), as well as twenty-one known compounds (3–23) were isolated from the roots of Tripterygium regelii. The structures of the new compounds were determined by 1D and 2D NMR spectra and HR-ESI-MS data. The known compounds were determined by comparing the 1D NMR data in the literature. All compounds were evaluated for anti-inflammatory activity using the LPS-induced RAW264.7 inflammatory cell model, and the results showed that compounds 1, 8-11, 15-16, and 20-21 had good anti-inflammatory activity (IC50 < 20 μM). The cytotoxicity of all compounds was tested by CCK-8 assay, using RAW264.7 cells. The results showed that all compounds had no cytotoxicity to RAW264.7 in the range of 0 ~ 200 μM.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeThe new (±)-bacillipyrrole A (1) and bacillipyrazine A (2), together with seven known compounds, were isolated from a culture of the Mariana Trench sediment-derived bacterium Bacillus subtilis SY2101 in rice medium. Structures of the new compounds were elucidated by their HRESIMS data and NMR spectroscopic analyses. The known compound 3,5,6-trimethylpyrazine-2-methyl acetate (4) showed antiproliferative activity against human glioma U87MG cells with an IC50 value of 22.6 ± 2.8 μM.
查看更多>>摘要：? 2022A phytochemical investigation of the EtOH extract of the roots of Rheum palmatum L. was performed, leading to the isolation of 3 new acylglycosides (1–3) and 19 previously reported compounds, including 4 cinnamoyl glucosides (4–7) and 15 anthraquinones (8–22). Their structures were elucidated using nuclear magnetic resonance, infrared, ultraviolet and high-resolution electrospray ionization mass spectra and X-ray diffraction data. The biological activities of compounds 2, 4–9, and 11–13, including their lymphocyte activation gene 3 (LAG3)/major histocompatibility complex class II (MHC II) and LAG3/fibrinogen-like protein 1 (FGL1) binding inhibition activities, were evaluated. Among the isolates, compound 7 exhibited clear inhibitory activity against the LAG3/FGL1 interaction with an IC50 of 7.89 μM, meanwhile compound 6 inhibited the LAG3/MHC II interaction with an IC50 of 6.00 μM.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo new eunicellin-based diterpenoids, coniferains A (1) and B (2), have been isolated from the soft coral Cladiella conifera. Structures of eunicellins 1 and 2 were elucidated by spectroscopic analysis and the structure of a known eunicellin, australin G, was revised.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeLysine specific demethylase 1 (LSD1), which is overexpressed in several human cancers and acts as a demethylase of histone 3, lysine 4 and lysine 9, has become an attractive therapeutic target for cancer therapy. Based on our previous systematic studies, withanolides are important secondary metabolites mostly from the Solanaceae family of plants, which are crucial agents for cancer treatment. Here, withanolides were characterized as LSD1 inhibitors, especially withaferin A, with an IC50 value of 3.04 μM. In vitro bioactivity assays and virtual molecular docking indicated that withaferin A could inhibit MDA-MB-231 cell migration by inhibiting intracellular LSD1 activity. These findings provide a new withanolide-based natural molecular skeleton for LSD1 inhibitors with potential antitumor activity.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeMiliusa sinensis Finet and Gagnep. have recently been subjected to numerous scientific studies pursuing its structure and biological properties. The chromatographic separation of the components from the methanolic extract of M. sinensis leaves yielded three new bisstyryls, namely, sinenbisstyryls A–C (1–3). The structures of the new compounds were determined via interpretation of their spectroscopic data. Of the isolated compounds, sinenbisstyryl A (1) exhibited cytotoxic activity against the A549 human lung, HepG2 human hepatocyte carcinoma, MCF7 human breast, and DU145 human prostate cancer cell lines, with IC50 values of between 11.46 μM and 19.01 μM in four cases.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo new aspidosperma-type alkaloids, taberibogines C and D (1 and 2), along with three known ones (3–5), were isolated from the leaves of Tabernaemontana bovina. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and X-ray crystal diffraction. Alkaloids 1-2 exhibited moderate inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages.
查看更多>>摘要：? 2022Two isomers of megastigmane glycosides, (6R, 9S)-blumenol C 9-O-gentibioside (2) and (6S, 9S)-blumenol C 9-O-gentiobioside (3), and a new 7,9′-dinorlignan glycoside, stepdonorlignoside (4) were isolated from the tubers of Stephania kaweesakii. The structure determinations were considered based on the physical data and spectroscopic evidence. The absolute configurations of two megastigmanes were determined for the first time. Additionally, ten known compounds were isolated: (6R, 9S)-blumenol C 9-O-β-D-glucopyranoside, (+)-isolariciresinol 3a-O-β-D-glucopyranoside, salidroside, N-trans-caffeoyltyramine, (R)-isococlaurine, (R)-isococlaurine 4′-O-β-glucopyranoside, (?)-oblongine, (+)-magnocurarine, fordianoside, and (?)-cyclanoline.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeThree new jatrophane polyesters, Euphopepluanones M-O (1–3), along with eight known ones (4-11), were isolated from the leaves of Euphorbia peplus Linn. Their chemical structures were established based on extensive spectroscopic analysis. The absolute configurations of compound 1 were assigned by X-ray crystallographic analysis. In addition, their anti-inflammatory effects on lipopolysaccharide-induced RAW264.7 macrophages were evaluated in vitro. Among them, 2 and 7 exhibited significant anti-inflammatory activity.
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Elsevier