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中华生物医学工程杂志
中华生物医学工程杂志

钟南山

双月刊

1674-1927

cjbme@vip.tom.com

020-81340157

510182

广东省广州市东风西路195号广州医学院内28栋1楼

中华生物医学工程杂志/Journal Chinese Journal of Biomedical EngineeringCSTPCD
查看更多>>中华医学会、广州医学院主办。本刊办刊宗旨：密切关注并报道生物医学工程学研究的新理论、新方法、新技术，跟踪生物医学工程学在临床中的最新应用成果，服务广大临床医生，促进生物医学工程学的学科发展。生物医学工程的发展一直是临床医学进步的动力，而临床医学所需要解决的问题则是生物医学工程创新的源泉。临床医生、科学家和产业界工程技术人员的紧密合作将为人类创造更美好的健康长寿的新生活。内容和栏目：（1）编者导读；（2）专论；（3）论著；（4）新技术与临床；（5）新技术研发；（6）生物技术；（7）综述；（8）专题讲座。
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    妊娠期糖尿病患者血清中人软骨糖蛋白39、弹性蛋白酶抑制剂、血清促代谢因子的表达及其与胰岛素抵抗的关系

    张秋妍郭慧涛毕慧霞朱改变...
    302-305页
    查看更多>>摘要：研究妊娠期糖尿病（GDM）患者血清中人软骨糖蛋白39（YKL-40）、弹性蛋白酶抑制剂（SerpinB1）、血清促代谢因子（Betatrophin）的表达及其与胰岛素抵抗的关系。研究发现GDM患者血清中YKL-40、SerpinB1、betatrophin的表达与胰岛素抵抗呈现出显著的相关性，可为临床诊断提供科学依据。 To investigate the expression of human cartilage glycoprotein 39 (YKL-40), elastase inhibitor (SerpinB1) and serum pro-metabolic factor (Betatrophin) in the serum of patients with gestational diabetes mellitus (GDM) and their relationship with insulin resistance. The expression of YKL-40, SerpinB1 and betatrophin in the serum of GDM patients showed a significant correlation with insulin resistance, which could provide a scientific basis for clinical diagnosis.

    妊娠期糖尿病人软骨糖蛋白39弹性蛋白酶抑制剂血清促代谢因子胰岛素抵抗

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    喉癌术后患者癌症复发恐惧现状与心理韧性、应对方式的关系

    王薇姣曲衍清张月琴张晓健...
    306-309页
    查看更多>>摘要：探讨喉癌术后患者癌症复发恐惧现状及与心理韧性、应对方式的关系。采用疾病进展恐惧简化量表（FoP-Q-SF）、心理韧性量表（CD-RISC）、简易应对方式量表（SCSQ）对116例喉癌术后患者进行调查。结果显示，喉癌术后患者癌症复发恐惧与心理韧性、积极应对方式呈负相关，与消极应对方式呈正相关（P<0.05）。喉癌术后患者均存在不同程度的癌症复发恐惧，且与心理韧性、积极应对方式呈负相关，与消极应对方式呈正相关。 To explore the status quo of fear of cancer recurrence and its relationship with psychological resilience and coping style in postoperative patients with laryngeal cancer. 116 postoperative patients with laryngeal cancer were investigated with fear of progression questionnaire short form (FoP-Q-SF), connor-davidson resilience scale (CD-RISC) and simplified coping style questionnai (SCSQ). The fear of cancer recurrence was negatively correlated with psychological resilience and positive coping style, and positively correlated with negative coping style (P<0.05). Postoperative laryngeal cancer patients have different degrees of cancer recurrence fear, which is negatively correlated with psychological resilience, positive coping style, and positively correlated with negative coping style.

    喉癌复发恐惧心理韧性应对方式

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    超声血流参数联合血清促甲状腺激素浓度对甲状腺癌患者淋巴结转移的评估价值

    史少华周世胜赵晓兰张翔...
    310-313页
    查看更多>>摘要：探究超声血流参数联合血清促甲状腺激素（TSH）浓度对甲状腺癌（TC）患者淋巴结转移的评估价值。回顾性选取TC患者107例，行多普勒超声检查，检测TSH表达，根据病理检查结果将患者分为淋巴转移组与未转移组。研究发现两组患者搏动指数（PI）和舒张末期血流速度（EDV）之间无明显差异（P>0.05），转移组阻力指数（RI）、收缩期峰值流速（PSV）和收缩期和舒张期流速比（S/D）、血清TSH均明显高于未转移组（P<0.05）。血流参数RI、PSV、S/D和血清TSH对于评估淋巴结转移的发生均有价值，其中血流参数与血清TSH联合检测的整体评估效能最高。 To explore the value of ultrasound blood flow parameters combined with serum thyrotropin (TSH) concentration in evaluating lymph node metastasis in patients with thyroid cancer (TC). 107 patients with TC were retrospectively selected for Doppler ultrasound examination to detect the expression of TSH. According to the pathological results, the patients were divided into lymphatic metastasis group and non-metastasis group. The study found that there was no significant difference between the two groups in pulsatile index (PI) and end-diastolic blood flow velocity (EDV) (P>0.05). The resistance index (RI), peak systolic flow velocity (PSV), systolic and diastolic flow velocity ratio (S/D) and serum TSH in the transfer group were significantly higher than those in the non-transfer group (P<0.05) .The blood flow parameters RI, PSV, S/D and serum TSH are all valuable for evaluating the occurrence of lymph node metastasis, and the combined detection of blood flow parameters and serum TSH has the highest overall evaluation efficiency.

    超声检查淋巴结促甲状腺激素甲状腺癌血流参数

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    下咽癌组织中前梯度蛋白2、S100钙结合蛋白A6表达水平与患者特征、临床结局的关系

    李滇汪旭周书芳张翔...
    314-318页
    查看更多>>摘要：分析下咽癌组织中前梯度蛋白2（AGR2）、S100钙结合蛋白A6（S100A6）表达水平及与患者特征、临床结局的关系。研究发现下咽癌组织中AGR2、S100A6表达水平均呈高表达，其表达水平与临床分期、分化程度、淋巴结转移有关，可作为预测下咽癌患者预后的生物标志物。 To explore the expression levels of pre-gradient protein 2 (AGR2) and S100 calcium-binding protein A6 (S100A6) in hypopharyngeal cancer tissues and their relationship with patient characteristics and clinical outcomes. High expression of AGR2 and S100A6 were independent risk factors for the prognosis of cases with hypopharyngeal carcinoma (P<0.05). The levels of AGR2 and S100A6 in hypopharyngeal carcinoma tissues are highly expressed, and their expression levels are related to clinical stage, differentiation degree and lymph node metastasis, which can be used as biomarkers to predict the prognosis of cases with hypopharyngeal carcinoma.

    下咽癌前梯度蛋白2S100钙结合蛋白A6临床病理特征临床结局

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    以内脏脂肪的面积为基础的常规CT检查联合多层螺旋CT血管成像对结直肠癌根治术患者的疗效预测价值分析

    朱慧刘刚张玥徐小虎...
    319-323页
    查看更多>>摘要：探讨以内脏脂肪的面积（VFA）为基础的常规CT检查联合多层螺旋CT血管成像（MSCTA）对结直肠癌根治术患者的疗效预测价值。术前CT测量VFA可准确评估结直肠癌患者腹部内脏脂肪信息，当VFA≥100 cm2会影响此类患者的手术效果并可增加术后并发症发生风险，同时MSCTA检查则是保护因素，从而有利于患者手术获益。 To investigate the predictive value of VFA-based conventional CT examination combined with MSCTA on the efficacy of patients undergoing radical colorectal cancer surgery. Preoperative CT measurement of VFA can accurately assess abdominal visceral fat information in patients with colorectal cancer, and when VFA ≥100 cm2 can affect the surgical outcome of such patients and can increase the risk of postoperative complications, while MSCTA examination is a protective factor, thus benefiting the patient.

    内脏脂肪面积多层螺旋CT血管成像结直肠癌根治术

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    三维超声分割肺头比值测量对肺隔离症胎儿诊断、预后的评估价值

    王琳曹晓焱张强朱少考...
    324-328页
    查看更多>>摘要：探讨基于3D-nnUnet三维超声分割测量胎儿隔离肺体积，计算肺头比值（CVR）在诊断隔离肺（PS）患儿及预后评估中的价值。研究发现产前三维超声的特征在鉴别诊断PS患儿与肺囊腺瘤患儿中具有较高的灵敏度，选取CRV临界值1.6和2.0作为预测PS患儿预后结局的灵敏度均不高，可以将超声特征与CRV临界值二者结合考虑，以提高CRV值的临床预测能力。 To explore the value of measuring fetal isolated lung volume and calculating the lung head ratio (CVR) based on 3D nnUnet three-dimensional ultrasound segmentation in the diagnosis and prognosis evaluation of isolated lung (PS) children. The study shows that the characteristics of prenatal three-dimensional ultrasound have high sensitivity in the differential diagnosis of children with PS and children with pulmonary cystadenoma. The sensitivity of selecting the CRV threshold value of 1.6 and 2.0 to predict the prognosis of children with PS is not high. The combination of ultrasound characteristics and CRV threshold value can be considered to improve the clinical prediction ability of CRV value.

    三维超声胎儿隔离肺肺头比值预后

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    107例宫颈癌放疗后放射性膀胱炎发生的相关因素分析

    何玲王振宇蔡文智张翔...
    329-335页
    查看更多>>摘要：回顾性分析宫颈癌患者的临床病理资料，根据患者接受根治性或术后放疗的情况分为单纯放疗组（42例）和术后放疗组（65例），依据常见不良反应事件评价标准（CTCAE V5.0），比较放射性膀胱炎（RIC）的发生概率，评价手术、病理分期、放疗总剂量和分次剂量以及膀胱和膀胱壁的放疗剂量体积参数对RIC发生率产生的影响。研究发现手术损伤导致的神经源性膀胱是造成膀胱毒性反应的可能原因，同时不排除放疗增加膀胱毒性反应的可能性。 To analyze the clinicopathological characteristics in patients with cervical cancer treated with chemoradiotherapy, or post-operational chemoradiotherapy, and to explore the high-risk factors associated with radiation-induced cystitis (RIC). 107 patients with cervical cancer was retrospectively recruited into the study who were treated with chemoradiotherapy alone, post-operational chemoradiotherapy, 42 and 65 patients, respectively. The surgical status, FIGO staging, total and fractionated doses of radiotherapy, and multiparameters including the dose and volume irradiated to the toltal bladder and bladder wall were evaluated for RIC. The combination of surgery and chemoradiotherapy may increase the incidence and severity of radiation-induced cystitis when compared to chemoradiotherapy alone suggesting that the neurogenic bladder caused by surgical injury is the main cause of bladder toxicity.

    宫颈癌放射治疗膀胱毒性放射性膀胱炎

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    真实世界研究:临床医生的主场优势

    方积乾张翔
    336-338页
    查看更多>>摘要：本讲座借助若干近期文献，推介国内外先行者基于临床大数据进行真实世界研究的成果与方法，以期激励更多临床医生利用主场优势，将真实世界研究与临床实践融为一体。

    真实世界研究医院为基础的队列研究电子病历

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    外泌体工程化改造在关节软骨修复中的研究进展

    刘佳硕冯凯谢雪涛张翔...
    339-344页
    查看更多>>摘要：关节软骨是一类不含血管、神经的组织。损伤后关节软骨难以实现自我修复。外泌体（exosomes）是细胞分泌的一类细胞外囊泡，直径在30 ~ 150 nm之间，含有多种生物活性物质。近年研究表明，外泌体可替代间充质干细胞（mesenchymal stem cells, MSCs）用于软骨组织的修复。但MSCs自然分泌的外泌体靶向性差、利用度低，含有的生物活性物质种类和含量有限，为解决这些问题以实现治疗效益最大化，需要利用工程化技术手段来改造外泌体。本文就外泌体工程化改造技术在关节软骨修复中的研究进展做一综述。

    外泌体工程化改造关节软骨

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    围生期心肌病临床诊断的研究进展

    杨燕颜素岚孙勇
    345-350页
    查看更多>>摘要：围生期心肌病是一种危害性较高的心肌病，该疾病在不同地域、种族的人群中发病率不同，目前病因尚未完全明确。因心力衰竭的症状和正常妊娠症状相重叠，其诊断易延误，预后较差。本综述旨在总结围生期心肌病临床诊断的研究进展。

    围生期心肌病诊断进展

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