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Phytochemistry Letters
Elsevier B.V.
Phytochemistry Letters

Elsevier B.V.

1874-3900

Phytochemistry Letters/Journal Phytochemistry LettersSCIISTP
正式出版
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    Cytotoxic isoflavonoids from the roots of Desmodium velutinum (Willd.) DC

    Kaweetripob W.Thongnest S.Boonsombat J.Kheawchaum S....
    7页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeA phytochemical investigation on the roots of Desmodium velutinum (Willd.) DC. afforded five pterocarpans, desmovelutins A–E and two isoflavans, desmovelisoflavans A and B, together with seven known compounds. Their structures were established by spectroscopic methods. Several isolated compounds were evaluated for their cytotoxic activities against four human cancer cell lines (A549, HepG2, HuCCA-1, and MOLT-3). Desmovelutin D, desmovelisoflavan A, 1-methoxyerythrabyssin II, gangetin, gangetial, and desmodin showed significant cytotoxicity against MOLT-3 cells with IC50 values in the range of 3.4?27.9 μM.
      原文链接:
    • NSTL
    • Elsevier

    N-containing compounds from Hymenocallis littoralis and their cytotoxicity against Hep3B cells

    Pang X.Liu C.-Y.Yu H.-Y.Han L.-F....
    3页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeA chemical study focusing on the N-containing constituents of Hymenocallis littoralis was carried out, leading to the isolation of two new alkaloidal flavonoids (1–2) and five known alkaloids (3-7). Structures of the isolated compounds were established mainly by spectroscopic techniques, including NMR spectroscopy and mass spectrometry as well as the CD experiment. These compounds were subjected to the in vitro cytotoxicity assays using Hep3B cells, and among them only the known pancratistatine (3) and lycorine (5) could significantly inhibit the Hep3B cell proliferation.
      原文链接:
    • NSTL
    • Elsevier

    Insulin mimetic lanostane triterpenes from the cultivated mushroom Ganoderma orbiforme

    Yang A.-A.Yan Y.-X.Shi P.-D.Yu C....
    5页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo new lanostane triterpenes, ganorbifoins A and B (1-2), together with the known compound (25S,3′S)-(+)-12α-hydroxy-3α-(3′-hydroxy-4′-methoxycarbonyl-3′-methylbutiryloxy)-24-methyllanosta-824-(31)-dien-26-oic acid (3) were isolated from the cultivated fruiting bodies of Ganoderma orbiforme. The structures of isolates were determined by extensive analysis of NMR and HRESIMS. All compounds induced glucose uptake in zebrafish-based system at the concentration of 10 μM. And the best performing compound is ganorbifoin A. Compounds 2 and 3 exhibited an inhibitory effect on nitric oxide production in LPS-induced BV-2 microglia cells at the concentration of 20 μM.
      原文链接:
    • NSTL
    • Elsevier

    A dinorcassane-type diterpene and a steroidal saponin from Distemonanthus benthamianus Baill. (Caesalpiniaceae)

    Kepdieu Tchebou R.V.Fouedjou R.T.Ponou B.K.Teponno R.B....
    6页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeAs part of our search for new bioactive compounds from medicinal plants growing in Cameroon, a previously unreported dinorcassane-type diterpenoid trivially named distemonanthin (1) and a new steroidal saponin, stigmasta-5,22-dien-3-O-β-D-glucopyranosyl-(1→3)-O-β-D-glucopyranoside (2) together with ten known compounds were isolated from the ethyl acetate and n-butanol soluble fractions of the methanol extract from the stem barks of Distemonanthus benthamianus. Their structures were established using 1D and 2D NMR spectroscopy, mass spectrometry and by comparison with spectroscopic data reported in the literature. The extract, fractions and some isolated compounds were screened for their antimicrobial properties and a significant inhibition was observed only for the n-butanol fraction against Candida albicans and Candida glabrata with MICs values of 32 and 64 μg/mL, respectively.
      原文链接:
    • NSTL
    • Elsevier

    Bioassay-guided isolation of antifungal cyclopeptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020

    Karim F.Liang X.Qi S.-H.
    4页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo new cyclopeptides simplicilliumtides N and O (1 and 2) along with three known analogues verlamelins A, B and simplicilliumtide J (3-5) were isolated from the deep-sea-derived fungal strain Simplicillium obclavatum EIODSF 020 by bioassay-guided isolation method. Their structures of 1 and 2 were elucidated by spectroscopic analysis, and their amino acid configurations were determined by Marfey's method. All isolated compounds showed significant antifungal activity against two phytopathogenic fungi Alternaria solani and Colletotricum asianum with MIC values of 0.195–6.250 μg/disc. This study suggests the fungal strain S. obclavatum EIODSF 020 is a new source for developing natural fungicides.
      原文链接:
    • NSTL
    • Elsevier

    Compounds from the fruits of Nicandra physaloides and their potential anti-inflammatory activities

    Liu Y.Jiang Y.-K.Naseem A.Algradi A.M....
    5页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwenty-one compounds were isolated and identified from the ethanol extract of the fruits of Nicandra physaloides, including four new (1–4) and 17 known compounds (5–21). All the compounds were isolated from the genus Physalis for the first time. In this study, NMR spectroscopy was used to study the compound structures by comparing their data with those reported in the literature. Moreover, the potential anti-inflammatory activity of RAW264.7 cells induced by lipopolysaccharide (LPS) was evaluated. Among the monoterpenoids, compounds (5–7, 9) exhibited weak anti-inflammatory activities, with IC50 values ranging from 29.10 to 68.30 μM.
      原文链接:
    • NSTL
    • Elsevier

    Acrocalysterols A and B, two new steroids from endophytic fungus Acrocalymma sp

    Liu J.Hu J.-Y.Duan D.-Z.Xiao J....
    4页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo new steroids, named acrocalysterols A (1) and B (2), together with five known compounds were isolated and characterized from an endophytic fungus Acrocalymma sp., isolated from the tender stems of Sinomenium acutum. The structures of the isolated metabolites were identified based on UV, IR NMR (1D and 2D), HR-ESI-TOF-MS, single-crystal X-ray diffraction experiment using Cu Kα radiation and CD spectra associated with TD-DFT calculation. The bioassay showed that compound 2 displayed potent cytotoxicity against three cancer cell lines HeLa, HCC-1806, and RKO with IC50 values ranging from 18.37 to 19.64 μM.
      原文链接:
    • NSTL
    • Elsevier

    Two new steroidal alkaloids from the mature fruits of Solanum nigrum

    Yang Y.Liu L.Wu T.Wang J....
    6页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo previously undescribed steroidal alkaloids, compounds 1–2, were isolated from the ripe fruits of Solanum nigrum, along with seven known metabolites (3–9). Based on spectroscopic and chemical evidence, including IR, NMR, and HR-ESI-MS analyses, the structures of the isolated compounds were elucidated as 12β-hydroxy-(3β,22α,25R)-spirosol-5-en-27-acid-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→3)]-β-D-galacopyranoside and 12β-hydroxy-(3β,22α,25R)-spirosol-5-en-27-acid-3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside. Four steroidal alkaloids (compounds 1–2 and 4–5) were tested for their anti-proliferative effects against the HT-29, A549, and Lewis cell lines. Both of the previously isolated compounds inhibited the proliferation of these three cell lines in a dose-dependent manner, with the most significant effect being in the A549 cells, but neither reached IC50 at 50 μM. These results revealed that S. nigrum had weak cytotoxicity, indicating its clinical safety as a traditional anti-tumor herbal medicine.
      原文链接:
    • NSTL
    • Elsevier

    Antidiabetic triterpenoids from the leaves of Paeonia suffruticosa and Paeonia delavayi

    Pan Y.Wu S.-L.Huang X.-Y.Hu J....
    7页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeThree new nor-oleanane triterpenoids, paeonenoides I-K (1-3), together with 13 known triterpenoids including nor-oleanane, oleanane, ursane, and cycloartane types, were isolated from the leaves of Paeonia suffruticosa and P. delavayi. The structures of the new compounds were elucidated with the aid of HRESIMS, 1D and 2D NMR, IR, and [α]D spectroscopic methods. Nine compounds (5-6, 8-11, 13-14 and 16) showed inhibition against PTP1B with IC50 values ranging from 36.5 to 192.6 μM, six compounds (5-6, 8-10 and 14) exhibited inhibitory activity against GPa with IC50 values ranging from 39.8 to 108.0 μM, and five compounds (1, 6, 10, 15 and 16) could significantly stimulate GLP-1 secretion by 100.2–313.4% (20 μM). Docking study demonstrated that compounds 5 and 6 strongly bonded with Gpa and PTP1B by salt bridges, hydrogen bonds and hydrophobic interactions, verifying the importance of carboxyl and hydroxyl groups. Especially, compounds 5 and 14 could simultaneously inhibit PTP1B and GPa with IC50 values of 57.8, 47.9 μM and 39.8, 45.2 μM, and compounds 6 and 10 could stimulate GLP-1 secretion by 293.6% and 313.4% at 20 μM.
      原文链接:
    • NSTL
    • Elsevier

    Resorcylic acid lactones from the ginseng pathogen Ilyonectria mors-panacis

    Walsh J.P.Sumarah M.W.Yeung K.K.-C.McMullin D.R....
    6页
    查看更多>>摘要：? 2022Ilyonectria mors-panacis, previously Cylindrocarpon destructans, is the main plant pathogen responsible for the fungal disease ginseng root rot. This economically important disease, also called disappearing root rot, reduces crop yields by an average of 30% at harvest. While the disease is well studied from ecological and genomic perspectives, the role of I. mors-panacis secondary metabolites in the disease process is not well understood. Our previous metabolomics study showed Ilyonectria strains that cause ginseng root rot produce mixtures of putative resorcylic acid lactones, whereas avirulent strains did not, and collectively synthesize fewer metabolites. To confirm these metabolomics findings, we isolated and characterized the secondary metabolites from I. mors-panacis DAOMC 251601, a strain that causes ginseng root rot. From its EtOAc soluble culture filtrate extract, eight resorcylic acid lactones (1-8), including chlorinated and non-chlorinated congeners, were characterized by HRMS and spectroscopic approaches (NMR, OR, UV). The structure of one new metabolite, named radicicol E (1), was elucidated and additional spectroscopic data for the known compound nordinonediol (2) are reported. Further, radicicol (9) production was confirmed by comparison to a standard. The roles that resorcylic acid lactones and the siderophore N,N′,N” triacetylfusarine C have in promoting Ilyonectria ginseng root rot are also discussed.
      原文链接:
    • NSTL
    • Elsevier