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国际免疫学杂志
国际免疫学杂志

李殿俊

双月刊

1673-4394

guojimianyi@126.com

0451-86669596

150081

黑龙江省哈尔滨市南岗区保健路157号

国际免疫学杂志/Journal International Journal of Immunology北大核心CSTPCD
查看更多>>1978年创刊，中华人民共和国卫生部主管，中华医学会、哈尔滨医科大学主办。本刊原名《国外医学》免疫学分册，公开发行的国家级学术期刊。期刊适合于从事免疫学以及相关学科、交叉学科的科研、教学和广大的临床医务工作者参考和交流。
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    耗竭CD4 ＋T细胞的免疫特点及免疫应用的研究进展

    李旭阳吕家誉韩敬泉徐进志...
    62-67页
    查看更多>>摘要：耗竭T细胞(exhausted T cell，Tex)的特征是细胞表面抑制性标记物表达增加，T细胞转录特点随之发生变化，进而表现为进行性和层次性免疫功能丧失。CD4＋T细胞在慢性感染或肿瘤环境下，会对其他浸润免疫细胞产生影响，参与肿瘤的病理进展和转归。研究表明，CD4＋T细胞在肿瘤微环境中会发生耗竭现象，这种耗竭现象可能与肿瘤的临床治疗效果直接相关。文章主要综述肿瘤中CD4＋Tex免疫学特点及免疫学功能，以期为肿瘤治疗提供新的靶点。 Exhausted T cells (Tex) are characterized by increased expression of cell-surface inhibitory markers and concomitant changes in T-cell transcriptional profiles, leading to a progressive and hierarchical immune dysfunction. CD4+ T cells can affect other infiltrating immune cells in chronic infection or tumor environments, participating in the pathological progression and prognosis of tumors. Researches have shown that CD4+ T cells can also be exhausted in tumor microenvironment, which may be directly related to the clinical treatment effectiveness of tumors. This review mainly summarizes the immunological characteristics and functions of CD4+ Tex in tumors, with the aim of providing new targets for tumor treatment.

    耗竭CD4＋T细胞肿瘤程序性死亡受体-1免疫检查点抑制剂

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    滤泡辅助性T细胞在HIV感染及疫苗免疫中的作用及机制

    李承乘杨瑶瑶张清燕李强...
    68-73页
    查看更多>>摘要：滤泡辅助性T细胞( follicular helper T cell，Tfh )是近期发现的具有B细胞辅助功能的CD4＋T淋巴细胞亚群，对于生发中心形成、亲和力成熟、高亲和力抗体产生和记忆B细胞的发育至关重要。Tfh与艾滋病(acquired immunodeficiency syndrome，AIDS)发展进程密切相关。在人类免疫缺陷病毒(human immunodeficiency virus，HIV)感染过程中，Tfh细胞数量、功能、病毒潜伏、Tfh/滤泡调节T细胞(follicular regulatory T cell，Tfr)比例平衡、中和抗体产生等方面均发生变化。文章综述Tfh在HIV感染及疫苗免疫后抗体应答中的作用及机制，旨在为HIV疫苗的设计与免疫策略制定提供参考。 Follicular helper T cells (Tfh) are a recently discovered subset of CD4+ T lymphocytes with B-cell auxiliary functions, which are essential for germinal center formation, affinity maturation, high-affinity antibody production, and memory B-cell development. Tfh is closely related to the development of acquired immunodeficiency syndrome (AIDS). In human immunodeficiency virus (HIV) infection, Tfh changes in cell number and function, virus latency, Tfh/follicular regulatory T cell(Tfr) ratio balance, neutralizing antibody production and other aspects. This review summarizes the role and mechanism of Tfh cells in HIV infection and antibody response after vaccine immunization, aiming to provide references for HIV vaccine design and immune strategy formulation.

    滤泡辅助性T细胞人类免疫缺陷病毒疫苗中和抗体

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    多发性硬化损伤的免疫机制研究进展

    于倩赵琳琳何敏张惊宇...
    74-78页
    查看更多>>摘要：多发性硬化(multiple sclerosis，MS)是中枢神经系统慢性自身免疫性炎性脱髓鞘疾病。既往研究主要探讨T淋巴细胞在MS中的作用，但近年来越来越多的证据表明B淋巴细胞在该病发生发展中发挥了重要作用。文章对T淋巴细胞、B淋巴细胞及细胞因子参与MS的发病机制及相关治疗药物进行概述，以期为MS的治疗提供新的思路。 Multiple sclerosis (MS) is a chronic autoimmune inflammatory demyelinating disease of the central nervous system. Previous studies have mainly explored the role of T lymphocytes in MS, but in recent years, more and more evidences have shown that B lymphocytes play an important role in the occurrence and development of this disease. This review summarizes the role of T lymphocytes, B lymphocytes, and cytokines in pathogenesis of MS and related therapeutic drugs, in order to provide new ideas for the treatment.

    多发性硬化T淋巴细胞B淋巴细胞细胞因子

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    外泌体在特应性皮炎中作用的研究进展

    万昊悦陈文琦
    79-82页
    查看更多>>摘要：外泌体是含有核酸、蛋白质、脂质、细胞因子、转录因子受体等生物活性分子的细胞外囊泡，几乎所有的细胞都可以分泌外泌体。外泌体在免疫应答、神经元之间的信号传导、生殖和发育等多方面发挥重要作用。近年来，关于外泌体在特应性皮炎(atopic dermatitis，AD)、银屑病、玫瑰痤疮等非感染性炎症性皮肤病方面的研究也取得了一定的进展。文章就外泌体在AD病情进展、诊断和临床治疗领域的研究结果进行综述，以期为AD临床诊断和治疗提供依据。 Exosomes are extracellular vesicles containing bioactive molecules such as nucleic acids, proteins, lipids, cytokines and transcription factor receptors. Almost all cells can secrete exosomes. Exosomes play important roles in immune response, signal transduction among neurons, reproduction, and development etc. In recent years, researches on exosomes in non infectious inflammatory skin diseases such as atopic dermatitis(AD), psoriasis, and rosacea have also made certain progress. This review summarrizes the research results of exosomes in the progression, diagnosis, and clinical treatment of AD, in order to provide a basis for the clinical diagnosis and treatment.

    外泌体特应性皮炎

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    巨噬细胞在肾纤维化发病机制和治疗中的研究进展

    郑仕清洪旭东许家龙陈爱芬...
    83-87页
    查看更多>>摘要：肾纤维化是肾脏组织受损后瘢痕修复的过程，是各种慢性肾脏病(chronic renal diseases，CKD)的最终结果。巨噬细胞参与炎症性肾脏疾病的发病过程并与CKD的纤维化进展密切相关。巨噬细胞表型和功能在整个病程中变化复杂，多种信号通路参与其中并介导纤维化的进程。文章概述了巨噬细胞表型和功能、在肾纤维化发病中的作用及靶向巨噬细胞对肾纤维化的治疗作用。 Renal fibrosis is the process of scar repair after renal tissue damage, and is the ultimate result of various chronic kidney diseases (CKD). Macrophages are involved in the pathogenesis of inflammatory kidney disease and closely related to the progression of CKD fibrosis. The phenotype and function of macrophages undergo complex changes throughout the entire disease process, with multiple signaling pathways involved and mediating the process of fibrosis. This review outlines the phenotype and function of macrophages, their role in the pathogenesis of renal fibrosis, and the therapeutic effect of targeted macrophages on renal fibrosis.

    巨噬细胞肾纤维化信号通路

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    细菌溶解产物治疗气道变应性疾病的研究进展

    李欣吕芸张玥钰何健...
    88-93页
    查看更多>>摘要：细菌溶解产物(bacterial lysates，BLs)是近年兴起的一种免疫调节剂，它可以通过调节体内的免疫系统从而增强机体的抗感染能力。BLs还可以通过改变辅助性T细胞(help T cell，Th)1/Th2平衡降低变态反应的发生率。以往关于BLs的研究主要集中在预防儿童和成人反复呼吸道感染中，近些年在变应性疾病中的应用逐渐增多。文章就BLs在变应性气道疾病中的作用机制及最新研究进展进行综述。 Bacterial lysate (BLs) are a newly rising immunomodulator in recent years, which can enhance the anti-infection ability of the body by regulating the immune system. BLs can also reduce the incidence of allergic reactions by altering helper T cell (Th)1/ Th2 balance. Previous studies on BLs mainly focused on the prevention of recurrent respiratory tract infections in children and adults. In recent years, the application of BLs in allergic diseases has gradually increased. This review summarizes the mechanism and the latest research progress of BLs in allergic airway diseases.

    细菌溶解产物气道高反应免疫反应变应性疾病

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    细胞因子与类风湿性关节炎成纤维样滑膜细胞

    李山山王皓周海舟
    94-98页
    查看更多>>摘要：类风湿性关节炎(rheumatoid arthritis，RA)是一种伴有多个关节肿、痛、畸形的免疫性疾病，严重情况下会引起关节功能的严重障碍，现已证实成纤维样滑膜细胞(fibroblast-like synoviocytes，FLS)与RA有极强的关联性，RA-FLS在RA发病机制中起关键作用。RA-FLS可自行产生多种炎性细胞因子，也可被某些细胞因子或物质刺激而产生多种炎性细胞因子，这些炎性细胞因子可增加RA-FLS的侵袭性和增殖能力，并减少RA-FLS的凋亡，从而进一步加重关节炎。文章重点探讨了几种可对RA-FLS产生影响的细胞因子，以期为治疗RA提供新的思路。 Rheumatoid arthritis (RA) is an immune disease with multiple joint swelling, pain and deformity, which can cause severe impairment of joint function in severe cases. Fibroblast-like synoviocytes (FLS) have been shown to have a strong association with RA, and plays a key role in the pathogenesis of RA. RA-FLS can produce a variety of inflammatory cytokines on its own, and also can be stimulated by certain cytokines or substances to produce a variety of inflammatory cytokines. These inflammatory cytokines can increase the aggressiveness and proliferative ability of RA-FLS and reduce the apoptosis of RA-FLS, thereby further aggravating arthritis. This review focuses on several cytokines that can have an impact on RA-FLS, in order to provide new ideas for the treatment of RA.

    成纤维样滑膜细胞肿瘤坏死因子-α白细胞介素-1β白细胞介素-6白细胞介素-17

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    肿瘤相关巨噬细胞对有氧糖酵解调控机制的研究进展

    章佳隆刘颖
    99-104页
    查看更多>>摘要：近年来有氧糖酵解和肿瘤相关巨噬细胞(tumor-associated macrophages，TAMs)在肿瘤微环境中的密切关系逐渐受到人们关注。TAMs不仅能够降低自身的糖酵解水平间接助长有氧糖酵解，还能通过特定的细胞因子和非编码RNA调控有氧糖酵解。这些机制是TAMs促进肿瘤生长、转移和抵抗化疗的重要因素，并且有望提供抗肿瘤治疗的新靶点。文章综述了TAMs调控有氧糖酵解机制，TAMs和有氧糖酵解对免疫逃逸的影响及与之相关的治疗策略。 In recent years, the intimate relationship between aerobic glycolysis and tumor-associated macrophages (TAMs) in the tumor microenvironment has garnered increasing attention. TAMs not only reduce their own glycolysis level to indirectly promote aerobic glycolysis, but also regulate aerobic glycolysis through specific cytokines and non-coding RNAs. These mechanisms are important factors for TAMs in promoting tumor growth, metastasis, and chemotherapy resistance, and are expected to provide new targets for anti-tumor treatment. Here we reviews the mechanism of TAMs in regulating aerobic glycolysis, the impact of TAMs and aerobic glycolysis on immune escape, and related treatment strategies.

    有氧糖酵解肿瘤相关巨噬细胞免疫逃逸抗肿瘤治疗

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    NFIL3在肿瘤进展和化疗耐药中的作用

    薛欣白富强薛阳
    105-108页
    查看更多>>摘要：核因子白细胞介素-3调节因子(nuclear factor interleukin-3-regulated factor，NFIL3)属于碱性亮氨酸拉链家族成员之一，在人体组织中广泛表达，参与多种生理功能，在人体免疫稳态中具有重要作用。研究发现NFIL3在多种类型的肿瘤组织中异常表达，参与肿瘤的发生和发展，并与肿瘤细胞的化疗耐药有关。文章就NFIL3在肿瘤进展和化疗耐药中的作用进行综述。 Nuclear factor interleukin-3 regulated factor(NFIL3) is a member of the alkaline leucine zipper family and is widely expressed in human tissues. It participates in various physiological functions and plays an important role in the immune homeostasis of the human body. Researches have found that NFIL3 is abnormally expressed in various types of tumor tissues, participating in the occurrence and development of tumors, and is related to the chemotherapy resistance of tumor cells. This review summarizes the role of NFIL3 in tumor progression and chemotherapy resistance.

    核因子白介素3调节因子肿瘤进展化疗耐药

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